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ANP32E

From Wikipedia, the free encyclopedia
ANP32E
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesANP32E, LANP-L, LANPL, acidic nuclear phosphoprotein 32 family member E
External IDsOMIM: 609611; MGI: 1913721; HomoloGene: 137403; GeneCards: ANP32E; OMA:ANP32E - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001136478
NM_001136479
NM_001280559
NM_001280560
NM_030920

NM_001253757
NM_001253758
NM_023210

RefSeq (protein)

NP_001129950
NP_001129951
NP_001267488
NP_001267489
NP_112182

NP_001240686
NP_001240687
NP_075699

Location (UCSC)Chr 1: 150.22 – 150.24 MbChr 3: 95.84 – 95.85 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene.[5][6] The ANP32E gene is located on chromosome 1q22.[5] In mammalian cells, ANP32E has been shown to be an H2A.Z chaperone capable of promoting the removal of H2A.Z from chromatin.[7] In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis[8] and has been observed to form a complex with ANP32A and SET that stabilizes short-lived mRNAs containing AU-rich elements, as well as having acetyltransferase inhibitory activity (in a complex with SET) and having a role in chromatin remodeling and transcriptional regulation.[9]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000143401Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015749Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b Jiang M, Ma Y, Ni X, Cao G, Ji C, Cheng H, Tang R, Xie Y, Mao Y (Nov 2002). "Molecular cloning and characterization of a novel human gene (ANP32E alias LANPL) from human fetal brain". Cytogenet Genome Res. 97 (1–2): 68–71. doi:10.1159/000064058. PMID 12438741. S2CID 30549428.
  6. ^ "Entrez Gene: ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E".
  7. ^ Obri A, Ouararhni K, Papin C, Diebold ML, Padmanabhan K, Marek M, Stoll I, Roy L, Reilly PT, Mak TW, Dimitrov S, Romier C, Hamiche A (2014). "ANP32E is a histone chaperone that removes H2A.Z from chromatin". Nature. 505 (7485): 648–53. Bibcode:2014Natur.505..648O. doi:10.1038/nature12922. PMID 24463511. S2CID 4406370.
  8. ^ Costanzo RV, Vilá-Ortíz GJ, Perandones C, Carminatti H, Matilla A, Radrizzani M (2006). "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309–24. doi:10.1111/j.1460-9568.2005.04555.x. PMID 16420440. S2CID 46587416.
  9. ^ Santa-Coloma, T.A. (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310–20. doi:10.1080/14734220310017212. PMID 14964690. S2CID 21454532.
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Further reading

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