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ALDH3B1

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(Redirected from ALDH3B1 (gene))
ALDH3B1
Identifiers
AliasesALDH3B1, ALDH4, ALDH7, aldehyde dehydrogenase 3 family member B1
External IDsOMIM: 600466; MGI: 1914939; HomoloGene: 73890; GeneCards: ALDH3B1; OMA:ALDH3B1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001290059
NM_000694
NM_001030010
NM_001161473
NM_001290058

NM_026316

RefSeq (protein)

NP_000685
NP_001025181
NP_001154945
NP_001276987
NP_001276988

NP_080592

Location (UCSC)Chr 11: 68.01 – 68.03 MbChr 19: 3.96 – 3.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Aldehyde dehydrogenase 3 family, member B1 also known as ALDH3B1 is an enzyme that in humans is encoded by the ALDH3B1 gene.[5][6]

Function

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The aldehyde dehydrogenases are a family of isozymes that may play a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation. This particular gene spans about 20 kb of genomic DNA and is composed of 9 coding exons. The gene encodes a single transcript of 2.8 kb that is highly expressed in kidney and lung. The functional significance of this gene and the cellular localization of its product are presently unknown. Two transcript variants encoding different isoforms have been found for this gene.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000006534Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024885Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hsu LC, Chang WC, Yoshida A (Dec 1994). "Cloning of a cDNA encoding human ALDH7, a new member of the aldehyde dehydrogenase family". Gene. 151 (1–2): 285–9. doi:10.1016/0378-1119(94)90672-6. PMID 7828891.
  6. ^ Hsu LC, Chang WC, Yoshida A (Apr 1997). "Human aldehyde dehydrogenase genes, ALDH7 and ALDH8: genomic organization and gene structure comparison". Gene. 189 (1): 89–94. doi:10.1016/S0378-1119(96)00839-6. PMID 9161417.
  7. ^ "Entrez Gene: ALDH3B1".
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Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.