Jump to content

AII amacrine cells

From Wikipedia, the free encyclopedia

AII amacrine cells are a subtype of amacrine cells. Amacrine cells are neurons that exist in the retina of mammals to assist in interpreting photoreceptive signals. AII amacrine cells serve the critical role of transferring light signals from rod photoreceptors to the retinal ganglion cells (which contain the axons of the optic nerve).

The AII amacrine cells are unique because they work primarily with the vertical transmission of information, meaning they connect the bipolar and ganglion cells. Other amacrine cells primarily assist with horizontal pathways, meaning they connect similar types of neurons[1][2].

The Classical Rod Pathway described the role of AII amacrine cells in the mammalian retina. This can be summarised as follows:[3][4]

(Once activated, the AII amacrine cell then modulates the cone ON and OFF channels):

  1. Other AII amacrine cells
  2. ON-cone bipolar cells

The ON- and OFF- cone bipolar cells in turn contact the ON- and OFF-centre retinal ganglion cells, respectively.

Note: A small proportion of rods contact the cone bipolar cells directly.

Footnotes

[edit]
  1. ^ There is only one type of rod bipolar cell: an ON-bipolar cell
  2. ^ This is a 'sign-inverting' synapse.
  3. ^ This is a 'sign-conserving' synapse.
  4. ^ This is usually a reciprocal synapse

References

[edit]


  1. ^ "Visual Processing: Eye and Retina (Section 2, Chapter 14) Neuroscience Online: An Electronic Textbook for the Neurosciences | Department of Neurobiology and Anatomy - The University of Texas Medical School at Houston". nba.uth.tmc.edu. Retrieved 2024-11-06.
  2. ^ Farsaii, Mahnoosh; Connaughton, Victoria P. (1995), Kolb, Helga; Fernandez, Eduardo; Jones, Bryan; Nelson, Ralph (eds.), "AII Amacrine Cells", Webvision: The Organization of the Retina and Visual System, Salt Lake City (UT): University of Utah Health Sciences Center, PMID 21413403, retrieved 2024-11-06
  3. ^ Farsaii M, Connaughton VP (July 2011). "AII Amacrine Cells". webvision.med.utah.edu.
  4. ^ Marc RE, Anderson JR, Jones BW, Sigulinsky CL, Lauritzen JS (4 September 2014). "The AII amacrine cell connectome: a dense network hub". Frontiers in Neural Circuits. 8: 104. doi:10.3389/fncir.2014.00104. PMC 4154443. PMID 25237297.