ADM2

ADM2
Identifiers
Aliases	ADM2, AM2, dJ579N16.4, adrenomedullin 2
External IDs	OMIM: 608682; MGI: 2675256; HomoloGene: 49801; GeneCards: ADM2; OMA:ADM2 - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,486,440 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,208,934 bp
RNA expression pattern
	Top expressed in
	body of pancreas; ; left lobe of thyroid gland; ; stromal cell of endometrium; ; right lobe of thyroid gland; ; duodenum; ; lymph node; ; renal cortex; ; salivary gland; ; bone marrow cells; ; human kidney;
	Top expressed in
	zygote; ; secondary oocyte; ; primary oocyte; ; morula; ; embryo; ; embryo; ; calvaria; ; right kidney; ; epiblast; ; blastocyst;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hormone activity; protein-containing complex binding;
Cellular component	extracellular region; intracellular anatomical structure;
Biological process	digestion; protein phosphorylation; positive regulation of gene expression; adenylate cyclase-activating G protein-coupled receptor signaling pathway; angiogenesis; feeding behavior; positive regulation of angiogenesis; negative regulation of blood pressure; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	79924
	223780
	ENSG00000128165
	ENSMUSG00000054136
	Q7Z4H4
	Q7TNK8
	NM_024866; NM_001253845; NM_001369882
	NM_182928
	NP_001240774; NP_001356811
	NP_891558
	Wikidata
View/Edit Human	View/Edit Mouse

ADM2 is a protein that in humans is encoded by the ADM2 gene.^[5]^[6]

ADM2 belongs to a family of calcitonin (MIM 114130)-related peptide hormones important for regulating diverse physiologic functions and the chemical composition of fluids and tissues.[supplied by OMIM]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000128165 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000054136 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.
^ ^a ^b "Entrez Gene: ADM2 adrenomedullin 2".

External links

Human ADM2 genome location and ADM2 gene details page in the UCSC Genome Browser.

Kawai M (2004). "[Diagnosis of dermatophytoses: conventional methods and recent molecular biological methods]". Nihon Ishinkin Gakkai Zasshi (Japanese Journal of Medical Mycology). 44 (4): 261–4. doi:10.3314/jjmm.44.261. PMID 14615790.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Roh J, Chang CL, Bhalla A, et al. (2004). "Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes". J. Biol. Chem. 279 (8): 7264–74. doi:10.1074/jbc.M305332200. PMID 14615490.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Takahashi K, Kikuchi K, Maruyama Y, et al. (2006). "Immunocytochemical localization of adrenomedullin 2/intermedin-like immunoreactivity in human hypothalamus, heart and kidney". Peptides. 27 (6): 1383–9. doi:10.1016/j.peptides.2005.11.004. PMID 16359754. S2CID 27665694.
Kindt F, Wiegand S, Löser C, et al. (2007). "Intermedin: a skin peptide that is downregulated in atopic dermatitis". J. Invest. Dermatol. 127 (3): 605–13. doi:10.1038/sj.jid.5700576. PMID 17008878.
Morimoto R, Satoh F, Murakami O, et al. (2007). "Expression of adrenomedullin2/intermedin in human brain, heart, and kidney". Peptides. 28 (5): 1095–103. doi:10.1016/j.peptides.2007.01.018. PMID 17346853. S2CID 23005775.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000128165 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000054136 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid14706825-5] Takei Y, Inoue K, Ogoshi M, Kawahara T, Bannai H, Miyano S (Jan 2004). "Identification of novel adrenomedullin in mammals: a potent cardiovascular and renal regulator". FEBS Lett. 556 (1–3): 53–8. doi:10.1016/S0014-5793(03)01368-1. PMID 14706825. S2CID 2063665.

[entrez-6] "Entrez Gene: ADM2 adrenomedullin 2".

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References

External links

Further reading