ADCK1

ADCK1
Identifiers
Aliases	ADCK1, aarF domain containing kinase 1
External IDs	OMIM: 620399; MGI: 1919363; HomoloGene: 6493; GeneCards: ADCK1; OMA:ADCK1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	77,935,014 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	88,428,494 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; skin of arm; ; gastrocnemius muscle; ; myocardium of left ventricle; ; gonad; ; muscle of thigh; ; ventral tegmental area; ; deltoid muscle; ; granulocyte; ; inferior ganglion of vagus nerve;
	Top expressed in
	saccule; ; otic placode; ; otic vesicle; ; spermatocyte; ; muscle of thigh; ; right kidney; ; spermatid; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; primary visual cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein serine/threonine kinase activity; ATP binding; kinase activity; nucleotide binding; transferase activity; protein binding;
Cellular component	extracellular region;
Biological process	protein phosphorylation; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	57143
	72113
	ENSG00000063761
	ENSMUSG00000021044
	Q86TW2
	Q9D0L4
NM_001142545; NM_020421; NM_001366485; NM_001366486; NM_001366487;
	NM_001366488; NM_001366489; NM_001366490
NM_001277296; NM_001277297; NM_028105; NM_001361598; NM_001361599;
	NM_001361600; NM_001361601
NP_001136017; NP_065154; NP_001353414; NP_001353415; NP_001353416;
	NP_001353417; NP_001353418; NP_001353419
NP_001264225; NP_001264226; NP_082381; NP_001348527; NP_001348528;
	NP_001348529; NP_001348530
	Wikidata
View/Edit Human	View/Edit Mouse

ADCK1 (aarF domain containing kinase 1) is an enzyme that in humans is encoded by the ADCK1 gene. It is situated on chromosome 14 at the q24.3 location.

Function

ADCK1 is predicted to possess ATP binding activity and protein serine/threonine kinase activity. It is involved in the negative regulation of mitochondrial fusion and the positive regulation of cristae formation within mitochondria. The protein is thought to be located predominantly in the mitochondrial inner membrane and may act as an integral component of the mitochondrial membrane.^[5]

Genomic context

The ADCK1 gene is located on chromosome 14q24.3. The genomic sequence spans 134,905 base pairs from 77,800,109 to 77,935,014 on the GRCh38.p14 primary assembly. It consists of 17 exons.^[5]

Expression

ADCK1 is ubiquitously expressed across various human tissues, with notable expression in the brain and thyroid, among others.^[5]

Clinical significance

Research indicates that ADCK1 may have therapeutic implications in diseases such as osteosarcoma and colon cancer.^[6] It has been observed to activate the beta-catenin/TCF signaling pathway, to promote the growth and migration of cancer cells.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000063761 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021044 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c "ADCK1 aarF domain containing kinase 1 [Homo sapiens (human)] - Gene". NCBI. Retrieved 2024-04-27.
^ Zhuo, BB; Zhu, LQ; Yao, C; Wang, XH; Li, SX; Wang, R; Li, Y; Ling, ZY (12 November 2022). "ADCK1 is a potential therapeutic target of osteosarcoma". Cell Death & Disease. 13 (11): 954. doi:10.1038/s41419-022-05401-8. PMC 9653483. PMID 36371387.
^ Ji, Y; Liu, Y; Sun, C; Yu, L; Wang, Z; Du, X; Yang, W; Zhang, C; Tao, C; Wang, J; Yang, X; Di, S; Huang, Y (6 April 2021). "ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells". Cell Death & Disease. 12 (4): 354. doi:10.1038/s41419-021-03624-9. PMC 8024291. PMID 33824271.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000063761 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021044 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[ncbi-5] "ADCK1 aarF domain containing kinase 1 [Homo sapiens (human)] - Gene". NCBI. Retrieved 2024-04-27.

[6] Zhuo, BB; Zhu, LQ; Yao, C; Wang, XH; Li, SX; Wang, R; Li, Y; Ling, ZY (12 November 2022). "ADCK1 is a potential therapeutic target of osteosarcoma". Cell Death & Disease. 13 (11): 954. doi:10.1038/s41419-022-05401-8. PMC 9653483. PMID 36371387.

[7] Ji, Y; Liu, Y; Sun, C; Yu, L; Wang, Z; Du, X; Yang, W; Zhang, C; Tao, C; Wang, J; Yang, X; Di, S; Huang, Y (6 April 2021). "ADCK1 activates the β-catenin/TCF signaling pathway to promote the growth and migration of colon cancer cells". Cell Death & Disease. 12 (4): 354. doi:10.1038/s41419-021-03624-9. PMC 8024291. PMID 33824271.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)