ADAMDEC1

ADAM-like, decysin 1 is a protein that in humans is encoded by the ADAMDEC1 gene. ^[1]

Function

This encoded protein is thought to be a secreted protein belonging to the disintegrin metalloproteinase family. Its expression is upregulated during the maturation of dendritic cells. This protein may play an important role in dendritic cell function and their interactions with germinal center T cells. [provided by RefSeq, Jul 2008].

References

^ "Entrez Gene: ADAM-like, decysin 1". Retrieved 2014-08-16.

Mueller, C. G.; Rissoan, M. C.; Salinas, B; Ait-Yahia, S; Ravel, O; Bridon, J. M.; Briere, F; Lebecque, S; Liu, Y. J. (1997). "Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells". The Journal of Experimental Medicine. 186 (5): 655–63. doi:10.1084/jem.186.5.655. PMC 2199019. PMID 9271581.
Bates, E. E.; Fridman, W. H.; Mueller, C. G. (2002). "The ADAMDEC1 (decysin) gene structure: Evolution by duplication in a metalloprotease gene cluster on chromosome 8p12". Immunogenetics. 54 (2): 96–105. doi:10.1007/s00251-002-0430-3. PMID 12037602. S2CID 32863451.
Fritsche, J; Müller, A; Hausmann, M; Rogler, G; Andreesen, R; Kreutz, M (2003). "Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation". Immunology. 110 (4): 450–7. doi:10.1111/j.1365-2567.2003.01754.x. PMC 1783081. PMID 14632642.
Crouser, E. D.; Culver, D. A.; Knox, K. S.; Julian, M. W.; Shao, G; Abraham, S; Liyanarachchi, S; Macre, J. E.; Wewers, M. D.; Gavrilin, M. A.; Ross, P; Abbas, A; Eng, C (2009). "Gene expression profiling identifies MMP-12 and ADAMDEC1 as potential pathogenic mediators of pulmonary sarcoidosis". American Journal of Respiratory and Critical Care Medicine. 179 (10): 929–38. doi:10.1164/rccm.200803-490OC. PMC 2684019. PMID 19218196.
Mueller, C. G.; Cremer, I; Paulet, P. E.; Niida, S; Maeda, N; Lebeque, S; Fridman, W. H.; Sautès-Fridman, C (2001). "Mannose receptor ligand-positive cells express the metalloprotease decysin in the B cell follicle". Journal of Immunology. 167 (9): 5052–60. doi:10.4049/jimmunol.167.9.5052. PMID 11673514.
Berger, M; Moscatelli, H; Kulle, B; Luxembourg, B; Blouin, K; Spannagl, M; Lindhoff-Last, E; Schambeck, C. M. (2008). "Association of ADAMDEC1 haplotype with high factor VIII levels in venous thromboembolism". Thrombosis and Haemostasis. 99 (5): 905–8. doi:10.1160/TH08-01-0059. PMID 18449420. S2CID 7494141.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: ADAM-like, decysin 1". Retrieved 2014-08-16.

[1]

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pregnancy-associated plasma protein A Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

Function

References

Further reading