ABRA (gene)

ABRA
Identifiers
Aliases	ABRA, STARS, actin binding Rho activating protein
External IDs	OMIM: 609747; MGI: 2444891; HomoloGene: 34713; GeneCards: ABRA; OMA:ABRA - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	106,770,244 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	41,733,116 bp
RNA expression pattern
	Top expressed in
	Skeletal muscle tissue of rectus abdominis; ; Skeletal muscle tissue of biceps brachii; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; deltoid muscle; ; right ventricle; ; muscle of thigh; ; gastrocnemius muscle; ; myocardium; ; body of tongue;
	Top expressed in
	interventricular septum; ; muscle of thigh; ; soleus muscle; ; knee joint; ; extraocular muscle; ; quadriceps femoris muscle; ; vastus lateralis muscle; ; digastric muscle; ; tibialis anterior muscle; ; gastrocnemius muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	actin binding;
Cellular component	cytoplasm; plasma membrane; sarcomere; myofibril; cytoskeleton; actin cytoskeleton;
Biological process	positive regulation of Rho protein signal transduction; protein transport; positive regulation of transcription, DNA-templated; positive regulation of DNA-binding transcription factor activity; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of transcription by RNA polymerase II; protein import into nucleus;
	Sources:Amigo / QuickGO
Orthologs
	137735
	223513
	ENSG00000174429
	ENSMUSG00000042895
	Q8N0Z2
	Q8BUZ1
	NM_139166
	NM_175456
	NP_631905
	NP_780665
	Wikidata
View/Edit Human	View/Edit Mouse

Actin-binding Rho-activating protein is a protein that in humans is encoded by the ABRA gene.^[5] The mouse and rat homologues are known as STARS (striated muscle activator of Rho signalling) and MS1 (myocyte stress 1) respectively.^[6]

MS1/STARS is regulated by MyoD during myogenic differentiation of the C2C12 cell line.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174429 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000042895 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Arai A, Spencer JA, Olson EN (Jul 2002). "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription". J Biol Chem. 277 (27): 24453–9. doi:10.1074/jbc.M202216200. PMID 11983702.
^ "Entrez Gene: ABRA actin-binding Rho activating protein".

External links

Human ABRA genome location and ABRA gene details page in the UCSC Genome Browser.

Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Kuwahara K, Barrientos T, Pipes GC, et al. (2005). "Muscle-specific signaling mechanism that links actin dynamics to serum response factor". Mol. Cell. Biol. 25 (8): 3173–81. doi:10.1128/MCB.25.8.3173-3181.2005. PMC 1069631. PMID 15798203.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Kuwahara K, Teg Pipes GC, McAnally J, et al. (2007). "Modulation of adverse cardiac remodeling by STARS, a mediator of MEF2 signaling and SRF activity". J. Clin. Invest. 117 (5): 1324–34. doi:10.1172/JCI31240. PMC 1838928. PMID 17415416.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174429 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000042895 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11983702-5] Arai A, Spencer JA, Olson EN (Jul 2002). "STARS, a striated muscle activator of Rho signaling and serum response factor-dependent transcription". J Biol Chem. 277 (27): 24453–9. doi:10.1074/jbc.M202216200. PMID 11983702.

[entrez-6] "Entrez Gene: ABRA actin-binding Rho activating protein".

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[6]

References

External links

Further reading