ABCC12

ABCC12
Identifiers
Aliases	ABCC12, MRP9, ATP binding cassette subfamily C member 12
External IDs	OMIM: 607041; MGI: 2441679; HomoloGene: 57211; GeneCards: ABCC12; OMA:ABCC12 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	48,156,018 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	87,307,315 bp
RNA expression pattern
	Top expressed in
	gonad; ; left testis; ; right testis; ; testicle; ; right frontal lobe; ; prefrontal cortex; ; Brodmann area 9; ; anterior cingulate cortex; ; muscle of thigh; ; primary visual cortex;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; spermatid; ; Leydig cell; ; seminal vesicula; ; lumbar subsegment of spinal cord; ; embryo; ; Sertoli cell; ; striatum of neuraxis; ; cerebellum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; ATP binding; ATPase-coupled transmembrane transporter activity;
Cellular component	integral component of membrane; membrane;
Biological process	transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	94160
	244562
	ENSG00000140798
	ENSMUSG00000036872
	Q96J65
	Q80WJ6
	NM_145190; NM_033226; NM_145187; NM_145188; NM_145189
	NM_172912
	NP_150229
	NP_766500
	Wikidata
View/Edit Human	View/Edit Mouse

Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ABCC12 gene.^[5]^[6]^[7]

Function

This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-binding domains and 12 transmembrane regions. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies: ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White. This gene is a member of the MRP subfamily which is involved in multi-drug resistance. This gene and another subfamily member are arranged head-to-tail on chromosome 16q12.1. Increased expression of this gene is associated with breast cancer.^[7] Loss of function is implicated in hereditary cholestasis.

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000140798 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036872 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.
^ Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, et al. (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.
^ ^a ^b "Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12".

External links

Human ABCC12 genome location and ABCC12 gene details page in the UCSC Genome Browser.

Adding link to ABCC12 gene details page and display in UCSC genome browser.

Haimeur A, Conseil G, Deeley RG, Cole SP (2004). "The MRP-related and BCRP/ABCG2 multidrug resistance proteins: biology, substrate specificity and regulation". Curr. Drug Metab. 5 (1): 21–53. doi:10.2174/1389200043489199. PMID 14965249.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Mammalian Gene Collection Program Team, Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proceedings of the National Academy of Sciences. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Bera TK, Iavarone C, Kumar V, et al. (2002). "MRP9, an unusual truncated member of the ABC transporter superfamily, is highly expressed in breast cancer". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6997–7002. Bibcode:2002PNAS...99.6997B. doi:10.1073/pnas.102187299. PMC 124517. PMID 12011458.
Yabuuchi H, Shimizu H, Takayanagi S, Ishikawa T (2001). "Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12". Biochem. Biophys. Res. Commun. 288 (4): 933–9. doi:10.1006/bbrc.2001.5865. PMID 11688999.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000140798 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036872 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11435397-5] Dean M, Rzhetsky A, Allikmets R (Jul 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Res. 11 (7): 1156–66. doi:10.1101/gr.184901. PMID 11435397. S2CID 9528197.

[pmid11483364-6] Tammur J, Prades C, Arnould I, Rzhetsky A, Hutchinson A, Adachi M, et al. (Aug 2001). "Two new genes from the human ATP-binding cassette transporter superfamily, ABCC11 and ABCC12, tandemly duplicated on chromosome 16q12". Gene. 273 (1): 89–96. doi:10.1016/S0378-1119(01)00572-8. PMID 11483364.

[entrez-7] "Entrez Gene: ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12".

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Function

References

External links

Further reading