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3alpha-hydroxyglycyrrhetinate dehydrogenase

From Wikipedia, the free encyclopedia
3-alpha-hydroxyglycyrrhetinate dehydrogenase
Identifiers
EC no.1.1.1.230
CAS no.114308-07-5
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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PMCarticles
PubMedarticles
NCBIproteins

In enzymology, a 3alpha-hydroxyglycyrrhetinate dehydrogenase (EC 1.1.1.230) is an enzyme that catalyzes the chemical reaction

3alpha-hydroxyglycyrrhetinate + NADP+ 3-oxoglycyrrhetinate + NADPH + H+

Thus, the two substrates of this enzyme are 3alpha-hydroxyglycyrrhetinate and NADP+, whereas its 3 products are 3-oxoglycyrrhetinate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3alpha-hydroxyglycyrrhetinate:NADP+ 3-oxidoreductase.

References

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  • Akao T, Akao T, Hattori M, Namba T, Kobashi K (March 1988). "Purification and properties of 3 alpha-hydroxyglycyrrhetinate dehydrogenase of Clostridium innocuum from human intestine". J. Biochem. 103 (3): 504–7. PMID 3164718.