3-Oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase
| 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 1.17.1.7 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase (EC 1.17.1.7, paaZ (gene)) is an enzyme with systematic name 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde:NADP+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction
- 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde + NADP+ + H2O 3-oxo-5,6-dehydrosuberyl-CoA + NADPH + H+
The enzyme from Escherichia coli is a bifunctional protein that also acts as EC 3.7.1.16, oxepin-CoA hydrolase.
References
[edit]- ^ Ferrández A, Miñambres B, García B, Olivera ER, Luengo JM, García JL, Díaz E (October 1998). "Catabolism of phenylacetic acid in Escherichia coli. Characterization of a new aerobic hybrid pathway". The Journal of Biological Chemistry. 273 (40): 25974–86. doi:10.1074/jbc.273.40.25974. PMID 9748275.
- ^ Ismail W, El-Said Mohamed M, Wanner BL, Datsenko KA, Eisenreich W, Rohdich F, Bacher A, Fuchs G (July 2003). "Functional genomics by NMR spectroscopy. Phenylacetate catabolism in Escherichia coli". European Journal of Biochemistry. 270 (14): 3047–54. doi:10.1046/j.1432-1033.2003.03683.x. PMID 12846838.
- ^ Teufel R, Mascaraque V, Ismail W, Voss M, Perera J, Eisenreich W, Haehnel W, Fuchs G (August 2010). "Bacterial phenylalanine and phenylacetate catabolic pathway revealed". Proceedings of the National Academy of Sciences of the United States of America. 107 (32): 14390–5. Bibcode:2010PNAS..10714390T. doi:10.1073/pnas.1005399107. PMC 2922514. PMID 20660314.
External links
[edit]- 3-oxo-5,6-dehydrosuberyl-CoA+semialdehyde+dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
