The draw for the second qualifying round was held on 23 March 2022. The seven teams which advance from the first qualifying round and Denov who has received a bye for first round play in this round.[2]
The draw for the third qualifying round was held on 25 March 2022. The four teams which advance from the second qualifying round play in this round.[3]
Updated to match(es) played on April 20, 2022. Source: Soccerway Notes:
^ abThe match between Orol Nukus and Andijon was cancelled due to Andijon was unable to travel to Nukus due to financial difficulties.[5] As a result Orol Nukus were given a 3–0 victory.
Updated to match(es) played on April 21, 2022. Source: Soccerway Rules for classification: 1) Points; 2) Goal difference; 3) Goals scored; 4) Drawing of lots.
In the knockout stage, each tie will be played as a single match. The winners, runners-up and the two best third-placed teams from the group stage will join the two participating clubs in the group stage of the 2022 AFC Champions League, Pakhtakor and Nasaf.[4]
The draw will held on 28 April 2022. For the draw the winners of the group will be in a separate pot, as well as with clubs that participate in the group stage of the AFC Champions League. The matches have been scheduled from August 21 to 25.[4][6]