^The Riga v Tre Fiori match, which kicked off on 17 September 2020, 19:00 (20:00 EEST), was suspended after 23 minutes due to strong winds and broken floodlights, then resumed on 18 September 2020, 09:00 (10:00 EEST).[2]
^Sileks played their home match at Toše Proeski Arena, Skopje, instead of their regular stadium Gradski stadion, Kratovo.
^Astana played their home match at Almaty Central Stadium, Almaty, instead of their regular stadium Astana Arena, Nur-Sultan.
^ abArarat-Armenia played their home matches at Vazgen Sargsyan Republican Stadium, Yerevan, instead of their regular stadium Yerevan Football Academy Stadium, Yerevan.
^ abSarajevo played their home matches at Bilino Polje Stadium, Zenica, instead of their regular stadium Koševo City Stadium, Sarajevo.
^KÍ played their home match at Tórsvøllur, Tórshavn, instead of their regular stadium Við Djúpumýrar, Klaksvík which did not meet UEFA requirements.
Note: Between the 1999–2000 and 2008–09 seasons, the competition was still known as the UEFA Cup. All seasons are included following the competition's absorption of the Cup Winners' Cup.