The 2005–06 Serie C2 was the football league season of ItalianSerie C2 for the years 2005 and 2006. It was divided into two phases: the regular season, played from August 28, 2005 to May 7, 2006, and the playoff phase. Once the regular season was over teams placed 2nd to 5th entered a playoff to determine the second team in each division to be promoted to Serie C1. At the same time, teams placed 14th to 17th entered a playout for the right to remain in Serie C2 the following season.
As usual, Serie C2 was composed by three divisions, whose teams were divided geographically. Division C2/A was mainly composed by Northern Italy and Sardinian teams, whereas division C2/B included North-Central and Central Italy teams, with the exception of two teams from Campania (Benevento and Cavese), and division C2/C was represented by teams hailing from Central-Southern Italy and Sicily.
Teams finishing first in the regular season, plus one team winning the playoff round from each division were promoted to Serie C1; teams finishing last in the regular season, plus two relegation playoff losers from each division were relegated to Serie D, losing also their professional club status. In all, six teams were promoted to Serie C1, and nine teams were relegated to Serie D.
^Carraro, Franco (16 August 2005). "C.U. N°64/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Retrieved 12 August 2015.
^Carraro, Franco (16 August 2005). "C.U. N°65/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Archived from the original(PDF) on 24 August 2015. Retrieved 11 July 2015.
^Carraro, Franco (16 August 2005). "C.U. N°67/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Retrieved 11 July 2015.
^Carraro, Franco (16 August 2005). "C.U. N°66/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Retrieved 12 August 2015.
^Carraro, Franco (16 August 2005). "C.U. N°68/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Retrieved 11 July 2015.
^Carraro, Franco (19 August 2005). "C.U. N°67/A (2005–06)"(PDF). Consiglio Federale (in Italian). FIGC. Retrieved 11 July 2015.