Group C of the 2001 Copa América was one of the three groups of competing nations in the 2001 Copa América. It comprised Bolivia, Costa Rica, Honduras, and Uruguay. Costa Rica and Honduras were invited to replace Argentina and Canada, who were originally drawn into this group but withdrew shortly before the start of the tournament. Group play ran from 13 to 19 July 2001.
Costa Rica won the group and faced Uruguay—the third-placed team of the same group and best-ranked third-placed team overall—in the quarter-finals. Honduras finished second and faced Brazil, the winners of Group B, in the quarter-finals. Bolivia finished fourth in the group, and were eliminated from the tournament.