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2-oxoaldehyde dehydrogenase (NAD+)

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2-oxoaldehyde dehydrogenase (NAD)
Identifiers
EC no.1.2.1.23
CAS no.37250-91-2
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In enzymology, a 2-oxoaldehyde dehydrogenase (NAD+) (EC 1.2.1.23) is an enzyme that catalyzes the chemical reaction

a 2-oxoaldehyde + NAD+ + H2O a 2-oxo acid + NADH + H+

The 3 substrates of this enzyme are 2-oxoaldehyde, NAD+, and H2O, whereas its 3 products are 2-oxo acid, NADH, and H+.

This enzyme participates in pyruvate metabolism.

Nomenclature

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This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2-oxoaldehyde:NAD+ 2-oxidoreductase. Other names in common use include:

  • alpha-ketoaldehyde dehydrogenase
  • methylglyoxal dehydrogenase
  • NAD+-linked alpha-ketoaldehyde dehydrogenase
  • 2-ketoaldehyde dehydrogenase
  • NAD+-dependent alpha-ketoaldehyde dehydrogenase
  • 2-oxoaldehyde dehydrogenase (NAD+)

See also

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References

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  • Monder C (1967). "Alpha-keto aldehyde dehydrogenase, an enzyme that catalyzes the enzymic oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 242 (20): 4603–9. PMID 4383524.
  • Ray M, Ray S (1982). "On the interaction of nucleotides and glycolytic intermediates with NAD-linked alpha-ketoaldehyde dehydrogenase". J. Biol. Chem. 257 (18): 10571–4. PMID 7107626.
  • Ray S, Ray M (1982). "Purification and characterization of NAD and NADP-linked alpha-ketoaldehyde dehydrogenases involved in catalyzing the oxidation of methylglyoxal to pyruvate". J. Biol. Chem. 257 (18): 10566–70. PMID 7107625.