2-furoyl-CoA dehydrogenase
Appearance
2-furoyl-CoA dehydrogenase | |||||||||
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Identifiers | |||||||||
EC no. | 1.3.99.8 | ||||||||
CAS no. | 9068-18-2 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
Gene Ontology | AmiGO / QuickGO | ||||||||
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In enzymology, a 2-furoyl-CoA dehydrogenase (EC 1.3.99.8) is an enzyme that catalyzes the chemical reaction
- 2-furoyl-CoA + H2O + acceptor S-(5-hydroxy-2-furoyl)-CoA + reduced acceptor
The 3 substrates of this enzyme are 2-furoyl-CoA, H2O, and acceptor, whereas its two products are S-(5-hydroxy-2-furoyl)-CoA and reduced acceptor.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is 2-furoyl-CoA:acceptor 5-oxidoreductase (hydroxylating). Commonly used names include furoyl-CoA hydroxylase, 2-furoyl coenzyme A hydroxylase, 2-furoyl coenzyme A dehydrogenase, and 2-furoyl-CoA:(acceptor) 5-oxidoreductase (hydroxylating). It employs one cofactor, copper.
References
[edit]- Kitcher JP, Trudgill PW, Rees JS (1972). "Purification and properties of 2-furoyl-coenzyme A hydroxylase from Pseudomonas putida F2". Biochem. J. 130 (1): 121–32. PMC 1174307. PMID 4655411.