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2,5-dioxopiperazine hydrolase

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2,5-dioxopiperazine hydrolase
Identifiers
EC no.3.5.2.13
CAS no.97599-45-6
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a 2,5-dioxopiperazine hydrolase (EC 3.5.2.13) is an enzyme that catalyzes the chemical reaction

2,5-dioxopiperazine + H2O glycylglycine

Thus, the two substrates of this enzyme are 2,5-dioxopiperazine and H2O, whereas its product is glycylglycine.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amides. The systematic name of this enzyme class is 2,5-dioxopiperazine amidohydrolase. Other names in common use include cyclo(Gly-Gly) hydrolase, and cyclo(glycylglycine) hydrolase.

References

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  • Suzuki Y, Uchida K (1985). "Multiple forms of alpha-glycosidase from pig duodenum". Agric. Biol. Chem. 49 (6): 1573–1581. doi:10.1271/bbb1961.49.1573.