The 1990 Grand Prix de Tennis de Lyon – Singles was an event of the 1990 Grand Prix de Tennis de Lyon men's tennis tournament that was played at the Palais des Sports de Gerland in Lyon, France from 15 October until 22 October 1990. The draw comprised 32 players and eight were seeded. John McEnroe was the defending champion, but did not participate this year. Sixth-seeded Marc Rosset won the singles title, defeating unseeded Mats Wilander, in the final, 6–3, 6–2.[1]