Benzgalantamine

Benzgalantamine
Clinical data
Trade names	Zunveyl
Other names	ALPHA-1062
AHFS/Drugs.com	Zunveyl
License data	US DailyMed: Benzgalantamine;
Routes of; administration	By mouth
Drug class	Cholinesterase inhibitor
ATC code	None;
Legal status
Legal status	US: ℞-only;
Identifiers
CAS Number	224169-27-1; 1542321-58-3;
DrugBank	DB19353;
UNII	XOI2Q0ZF7G; LN7PMJ4P57;
KEGG	D12930; D12931;
ChEMBL	ChEMBL5095056;
Chemical and physical data
Formula	C24H25NO4
Molar mass	391.467 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COc1ccc2c3c1O[C@H]1C[C@@H](OC(=O)c4ccccc4)C=C[C@@]31CCN(C)C2;
	InChI InChI=1S/C24H25NO4/c1-25-13-12-24-11-10-18(28-23(26)16-6-4-3-5-7-16)14-20(24)29-22-19(27-2)9-8-17(15-25)21(22)24/h3-11,18,20H,12-15H2,1-2H3/t18-,20-,24-/m0/s1; Key:JKVNJTYHRABHIY-WXVUKLJWSA-N;

Benzgalantamine, sold under the brand name Zunveyl, is a medication used for the treatment of mild to moderate dementia of the Alzheimer's type.^[1] It is a cholinesterase inhibitor.^[1] Benzgalantamine is a prodrug of galantamine.^[1]

Benzgalantamine was approved for medical use in the United States in July 2024.^[1]^[2]^[3]

Medical uses

Benzgalantamine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type in adults.^[1]^[2]

The most common side effects include nausea, vomiting, diarrhea, dizziness, headache, and decreased appetite.^[1]

Benzgalantamine was approved for medical use in the United States in July 2024.^[1]^[2]

^ ^a ^b ^c ^d ^e ^f ^g ^h ⁱ "Zunveyl- benzgalantamine tablet, delayed release". DailyMed. 8 August 2024. Retrieved 15 August 2024.
^ ^a ^b ^c https://www.accessdata.fda.gov/drugsatfda_docs/appletter/2024/218549Orig1s000ltr.pdf
^ "Alpha Cognition's Oral Therapy Zunveyl Receives FDA Approval to Treat Alzheimer's Disease" (Press release). Alpha Cognition. 29 July 2024. Archived from the original on 4 August 2024. Retrieved 4 August 2024 – via Business Wire.
^ World Health Organization (2022). "International nonproprietary names for pharmaceutical substances (INN): recommended INN: list 88". WHO Drug Information. 36 (3). hdl:10665/363551.

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