YoungSoo Kim
YoungSoo Kim | |
|---|---|
| 김영수 | |
 | |
| Born | April 7, 1978 |
| Alma mater | New York University, Scripps Research |
| Scientific career | |
| Fields | Chemical Biology |
| Doctoral advisor | Kim D. Janda |
| Website | http://chembio.yonsei.ac.kr |
YoungSoo Kim (Korean: 김영수; born April 7, 1978) is a South Korean chemist. Kim is an associate professor in Department of Pharmacy at Yonsei University.
Education
[edit]Kim completed his B.A. degree in biochemistry from New York University in 2001, with Professor Young-Tae Chang as an undergraduate research advisor. He then studied bioorganic chemistry under the supervision of Professor Kim D. Janda at Scripps Research and obtained his Ph.D. degree[1] in chemistry in 2006.
Academic career
[edit]In 2006, Kim joined Korea Institute of Science and Technology (KIST) as a research scientist. In 2010, after his military service duty, he became a principal investigator of Brain Science Institute at KIST and associate professor of biological chemistry at Korea University of Science and Technology (UST). In 2017, he moved to Yonsei University as an assistant professor of bio-convergence (ISED) and pharmacy. In 2020, he was promoted to an associate professor of pharmacy.
In addition to Department of Pharmacy, Kim is affiliated in three other departments of Yonsei; Integrated Science and Engineering Division (ISED), of Underwood International College (UIC), Graduate Program of Integrative Biotechnology and Translational Medicine (IBTM), and Graduate Program of Industrial Pharmaceutical Sciences. Kim is an adjunct professor of POSTECH.[2]
Editorial career
[edit]Kim is an editorial board member (neurology section) of Scientific Reports,[3] academic editor of PLOS ONE,[4] executive editor of Experimental Neurobiology.[5]
Research
[edit]His laboratory is located at Yonsei University International Campus[6][7] in Songdo International Business District. Kim's work focuses on pathology, therapeutics, and diagnostics of Alzheimer's disease by using Chemical Biology as a research tool. A significant effort of the Kim laboratory in recent years has been to identify small molecules that control protein misfolding and cognitive impairments of Alzheimer's disease. Such research achievements in taurine derivatives reversing Alzheimer pathology[8][9] and Alzheimer blood tests detecting plasma amyloid-beta[10][11][12][13][14] contributed to rank Korea Institute of Science and Technology #6 among The World's Most Innovative Research Institutions, selected by Reuters, in 2016[15] and 2017.[16] His recent review article[17] about fluid biomarkers of Alzheimer's disease published in Experimental & Molecular Medicine was selected in Springer Nature 2019 Highlights.[18] Examples of such molecules discovered include:
- EPPS, a small molecule disaggregating amyloid-beta oligomers and plaques[8][14][19][20][21]
- Taurine, a food supplement recovering learning and memory[9]
- Necrostatin-1, an anti-necroptotic molecule regulating both amyloid-beta misfolding and tau hyperphosphorylation[22]
- CLASS (Comparing Levels of Aβ by Self-Standard), a blood test method to diagnose Alzheimer's disease[14]
- Drug repositioning for chemical-driven clearance of amyloid plaques[23]
- Chemical-driven outflow of dissociated amyloid burden from brain to blood[24]
Commercial activity
[edit]He is a co-founder and CSO of Amyloid Solution.
External links
[edit]References
[edit]- ^ "TSRI Kellogg School's Entering Class in 2002".
- ^ "POSTECH and Yonsei University to Create Blockchain Campus Together". BusinessKorea (in Korean). 2019-04-03. Retrieved 2020-03-11.
- ^ "Editorial Advisory Panel and Editorial Board". Scientific Reports.
- ^ "PLOS ONE Editorial Board – Academic Editors".
- ^ "Experimental Neurobiology". www.en-journal.org. Retrieved 2022-10-28.
- ^ "Underwood International College – Faculty Page". Yonsei University. Retrieved 2017-05-13.
- ^ "College of Pharmacy". Yonsei University. Retrieved 2017-05-13.
- ^ a b Yun Kim, Hye (2015). "EPPS rescues hippocampus-dependent cognitive deficits in APP/PS1 mice by disaggregation of amyloid-β oligomers and plaques". Nature Communications. 6: 8997. Bibcode:2015NatCo...6.8997K. doi:10.1038/ncomms9997. PMC 4686862. PMID 26646366.
- ^ a b Yun Kim, Hye; Kim, Hyunjin V.; Yoon, Jin H.; Ram Kang, Bo; Min Cho, Soo; Lee, Sejin; Yoon Kim, Ji; Won Kim, Joo; Cho, Yakdol; Woo, Jiwan; Kim, YoungSoo (2014). "Taurine in drinking water recovers learning and memory in the adult APP/PS1 mouse model of Alzheimer's disease". Scientific Reports. 4: 7467. Bibcode:2014NatSR...4E7467K. doi:10.1038/srep07467. PMC 4264000. PMID 25502280.
- ^ Min Cho, Soo; Vincent Kim, Hyunjin; Lee, Sejin; Yun Kim, Hye; Kim, Woong; Song Kim, Tae; Jin Kim, Dong; Kim, YoungSoo (2014). "Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model". Scientific Reports. 4: 6777. Bibcode:2014NatSR...4E6777C. doi:10.1038/srep06777. PMC 4209448. PMID 25345439.
- ^ Min Cho, Soo; Lee, Sejin; Yang, Seung-Hoon; Yun Kim, Hye; Jisoo Lee, Michael; Vincent Kim, Hyunjin; Kim, Jiyoon; Baek, Seungyeop; Yun, Jin; Kim, Dohee; Kyung Kim, Yun; Cho, Yakdol; Woo, Jiwan; Song Kim, Tae; Kim, YoungSoo (2015). "Age-dependent inverse correlations in CSF and plasma amyloid-β(1–42) concentrations prior to amyloid plaque deposition in the brain of 3xTg-AD mice". Scientific Reports. 6: 20185. doi:10.1038/srep20185. PMC 4735736. PMID 26830653.
- ^ Yang, Seung-Hoon; Kim, Jiyoon; Jisoo Lee, Michael; Kim, YoungSoo (2015). "Abnormalities of plasma cytokines and spleen in senile APP/PS1/Tau transgenic mouse model". Scientific Reports. 5: 15703. Bibcode:2015NatSR...515703Y. doi:10.1038/srep15703. PMC 4621607. PMID 26503550.
- ^ "Early Dementia Diagnosis Based on Blood Test to Become Possible in 2019". Business Korea. 2016.
- ^ a b c Kim, Youngsoo; Yoo, Yong Kyoung; Kim, Hye Yun; Roh, Jee Hoon; Kim, Jinsik; Baek, Seungyeop; Lee, Jinny Claire; Kim, Hye Jin; Chae, Myung-Sic; Jeong, Dahye; Park, Dongsung; Lee, Sejin; Jang, Hochung; Kim, Kyeonghwan; Lee, Jeong Hoon; Byun, Byung Hyun; Park, Su Yeon; Ha, Jeong Ho; Lee, Kyo Chul; Cho, Won Woo; Kim, Jae-Seung; Koh, Jae-Young; Lim, Sang Moo; Hwang, Kyo Seon (2019). "Comparative analyses of plasma amyloid-β levels in heterogeneous and monomerized states by interdigitated microelectrode sensor system". Science Advances. 5 (4): eaav1388. Bibcode:2019SciA....5.1388K. doi:10.1126/sciadv.aav1388. PMC 6469948. PMID 31001580.
- ^ "Top 25 Global Innovators – #6 Korea Institute of Science & Technology in 2016". Reuters.
- ^ "Top 25 Global Innovators – #6 Korea Institute of Science & Technology in 2017". Reuters.
- ^ Lee, Jinny Claire; Kim, Soo Jung; Hong, Seungpyo; Kim, YoungSoo (2019). "Diagnosis of Alzheimer's disease utilizing amyloid and tau as fluid biomarkers". Experimental & Molecular Medicine. 51 (5): 1–10. doi:10.1038/s12276-019-0250-2. ISSN 2092-6413. PMC 6509326. PMID 31073121.
- ^ "Springer Nature 2019 Research Highlights". www.springernature.com. Retrieved 2020-03-11.
- ^ "Molecule clears Alzheimer's plaques in mice". BBC. 2015.
- ^ "Taurine-like chemical restores cognitive function in mice with Alzheimer's". The Guardian. 2015.
- ^ Yun Kim, Hye; Vincent Kim, Hyunjin; Lee, Dongkeun K.; Yang, Seung-Hoon; Kim, YoungSoo (2016). "Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil". Scientific Reports. 6: 34165. Bibcode:2016NatSR...634165K. doi:10.1038/srep34165. PMC 5086916. PMID 27796293.
- ^ "Nec‐1 alleviates cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mic". EMBO Molecular Medicine. 2017.
- ^ Lee, Jinny Claire; Kim, Hye Yun; Lee, Sejin; Shin, Jisu; Kim, Hyunjin Vincent; Kim, Kyeonghwan; Baek, Seungyeop; Lee, Donghee; Jeon, Hanna; Kim, DaWon; Yang, Seung‐Hoon; Han, Gyoonhee; Park, Keunwan; Choi, Jaeho; Park, Jinwoo (2020-07-06). "Discovery of Chemicals to Either Clear or Indicate Amyloid Aggregates by Targeting Memory‐Impairing Anti‐Parallel Aβ Dimers". Angewandte Chemie International Edition. 59 (28): 11491–11500. doi:10.1002/anie.202002574. ISSN 1433-7851. PMID 32233096. S2CID 214748857.
- ^ Lee, Donghee; Kim, Hyunjin Vincent; Kim, Hye Yun; Kim, YoungSoo (2022). "Chemical‐Driven Outflow of Dissociated Amyloid Burden from Brain to Blood". Advanced Science. 9 (12): 2104542. doi:10.1002/advs.202104542. ISSN 2198-3844. PMC 9036038. PMID 35106958.
