User talk:JinCheng9595/sandbox

HMB436 Peer commentary

Hi JinCheng, I'm a classmate of yours from HMB436. Overall, you have done a good job dividing your information under the different headings. However, I am unsure why you put two separate points regarding growth. Maybe you should consider moving the point from physiology under the growth header? You should also consider making a section on epidemiolgy. Also, don't forget to make your taxobox! Lastly, you should put a brief intro of your fungus (you can always take a look at the sample articles the professor provided us on the course page (eg. https://en.wikipedia.org/wiki/Aspergillus_ochraceus) Keep up the work :)

--Cjchan2016 (talk) 16:44, 29 October 2015 (UTC)[reply]

HMB436 Feedback

Hi, I'm going to leave some feedback on your article here. I hope you find it helpful.

Content suggestions and suggestions for additional sections:

You still need to add a taxobox. Information on the taxonomic categorization of your fungi can be found on Index Fungorum, and information on how to create a taxobox can be found on the course wiki page.
I would suggest you add a section on pathogenesis where you discuss how your C. tropicalis causes disease in humans (rather than just stating that it does and giving case examples as you have done so far). Elaborating on its pathogenesis is particularly important for your fungus, as it is in the Candida genus, and Candida spp. are particularly known to act as opportunistic pathogens, meaning that they infect immunocompromised hosts, whilst they're usually commensal in healthy humans.
Some of the points you currently have under " Epidemiology ", such as the fact that it causes systemic / invasive infections should then be moved under your new pathogenesis section rather than being under Epidemiology.
To expand you epidemiology section, you could include a paragraph explaining how the global HIV pandemic has shaped the incidence and prevalence of Candida infections, as immunocompromised aids patients are more susceptible to candida infections, so HIV-concomitant candidiasis would be an interesting issue to explore.
you could add a section on identification methods, ie. are there any biochemical tests that facilitate the differentiation of Candida tropicalis from other candida species?
Lastly, Candida species (especially albicans) are very important model organisms for research in cellular biology and genetics, so I looked into whether this is also the case for Candida tropicalis specifically. Although Candida albicans is far more widely used as a research model, Candida tropicalis is apparently used to study the biogenesis of peroxisomes (an organelle present in most eukaryotes), as well as mechanisms of drug resistance to antifungals, so these are some very relevant research applications that you should look into further! (this information is taken from the first source listed under source suggestions below).

Source Suggestions:

"Interspecific Complementation Analysis by Protoplast Fusion of Candida tropicalis and Candida albicans Adenine Auxotrophs", by Corner and Poulter
"Candida tropicalis: its prevalence, pathogenicity and increasing resistance to fluconazole." by Kothavada et al.

(you can search these by title on the U of T Libraries website to find the full-texts and citations)

I hope this helped!

Lena8F (talk) 21:50, 30 October 2015 (UTC)[reply]

Some food for thought from a dear classmate

Hi User:JinCheng9595, Wow other people sure did beat me to the punch. Anyway, I still think it is a great start to your page. I like how you have included the epidemiology aspect into this as well.

I noticed that you said that it is pathogenic like Candida Albicans, I believe you can you use this point to branch off and look into more aspects of its pathogenicity. Like how strong of a pathogen it is and something like that.

You said that it can invade human blood vessels but very little invade tissues, I just found that to be a bit confusing. I’d recommend you give a little more detail about what you mean by that because if it is blood invasive then what does it do after it invades the blood?

also since it can live in the human body that may tell you that its optimal growth temperature may be somewhere around our body temperature. Try and find out if you can what that temperature is.

One more thing, I think you ought to add a new heading for Pathogenicity. I highly reccomend that you do so, just as another classmate mentioned it as well, because under all of your other subheadings you hint at that this fungi causes disease and is pathogenic. I think it would be beneficial to the reader if you could just take all those related points and put them into a new heading so it’s easier to find everything about pathogenicity in one spot.

I think if you like you could include or mention some case studies of it infecting people and whether it is something lethal or treatable. This will make it more interesting to the reader and who doesn't love more information.

I looked at the page that already exists for your fungi and saw that it mentioned this fungus may be useful in biodiesal production^[1]. This is an interesting topic and could help show that this fungus has a useful side other than being an infectious fungi.

other than that I think you are off to a good start and best of luck

^ Karatay, SE; Dönmez, G (October 2010). "Improving the lipid accumulation properties of the yeast cells for biodiesel production using molasses". Bioresource technology. 101 (20): 7988–90. PMID 20542422.

[Biodiesal-1] Karatay, SE; Dönmez, G (October 2010). "Improving the lipid accumulation properties of the yeast cells for biodiesel production using molasses". Bioresource technology. 101 (20): 7988–90. PMID 20542422.

[1]