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Many single-game baseball feats have been accomplished a small enough number of times that a full enumeration is useful and practical. This is a listing of feats where this has been done, in decreasing order of rarity.
Accomplishment
Count
First
Date
Latest
Date
Four triples in one game
2
George Strief
June 25, 1885
Bill Joyce
May 18, 1897
Home runs by four consecutive batters
6
Milwaukee Braves
Jun. 8, 1961
Chicago White Sox
Aug. 14, 2008
Six strikeouts by a batter in a game
8
Carl Weilman
July 25, 1913
Geoff Jenkins
June 8, 2004
Two grand slams in one game
12
Tony Lazzeri
May 24, 1936
Bill Mueller
July 29, 2003
Unassisted triple play
14
Neal Ball
July 19, 1909
Asdrúbal Cabrera
May 12, 2008
Four home runs in a game
15
Bobby Lowe
May 30, 1894
Carlos Delgado
September 25, 2003
Perfect game
17
John Lee Richmond
June 12, 1880
Randy Johnson
May 18, 2004
Eighteen or more strikeouts
24
Charlie Sweeney
June 7, 1884
Ben Sheets
May 16, 2004
Strike out side on nine pitches
41
John Clarkson
June 4, 1889
Félix Hernández
June 17, 2008
Home run in first career at-bat
101
Joe Harrington
September 10, 1895
Mark Saccomanno
September 8, 2008
No-hitter
257
George Bradley
July 15, 1876
Carlos Zambrano
September 14, 2008
Hitting for the cycle
284
Curry Foley
May 25, 1882
Adrián Beltré
September 1, 2008
Three home runs in a game
480
Ned Williamson
May 30, 1884
Evan Longoria
September 18, 2008