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MrLaffo
— Wikipedian  —
Name
David "Laffo" Coast
Born (1874-01-01) January 1, 1874 (age 150)
Current locationSão Paulo
Contact info
Emaildavidmrkl@outlook.com
Twitter14dcoast
Babel user information
pt-N Este utilizador tem como língua materna o português.
en-5 This user has professional knowledge of English.
Users by language
This user is a
Registered Editor
and is entitled to display this Service Badge.

Hello there! I am Laffo, Welcome to my Wikipedia page.

I'm a fellow user who reads pages most of the times, but sometimes I edit.

If you have anything to say, go to my talk page.


Thanks for reading!

Random Crap

[edit]

Laura Moser
Personal details
Born (1977-08-30) August 30, 1977 (age 47)
Houston, Texas, U.S.
Political partyDemocratic
EducationAmherst College (BA)

Laura Moser (born August 30, 1977)[1] is an American author and politician who founded the anti-Trump resistance movement Daily Action. She was a candidate for the United States Congress in Texas's 7th congressional district.[2]



2010 World Junior Wrestling Championships
Host cityHungary Budapest, Hungary
Dates19–25 July 2010
Champions
Freestyle Russia
Greco-Roman Russia
Women Russia

The 2010 World Junior Wrestling Championships were the 33rd edition of the World Junior Wrestling Championships and were held in Budapest, Hungary between 19 and 25 July 2010.[3][4][5][6][7][8][9][10]

MrLaffo
Clinical data
Trade namesBelsomra
Other namesMK-4305; MK4305
AHFS/Drugs.comMonograph
MedlinePlusa614046
License data
Pregnancy
category
Dependence
liability
Low
Addiction
liability
Low
Routes of
administration
By mouth[12]
Drug classOrexin receptor antagonist; Hypnotic; Sedative
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability82% (10 mg; lower at higher doses)[12][16]
Protein binding99.5%[17][12]
MetabolismLiver (CYP3A major, CYP2C19 minor)[12]
MetabolitesHydroxysuvorexant (inactive)[12]
Elimination half-life12.2 hours (8–19 hours) (40 mg)[12][16][18]
ExcretionFeces: 66%[12]
Urine: 23%[12]
Identifiers
  • [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
Chemical and physical data
FormulaC23H23ClN6O2
Molar mass450.93 g·mol−1
3D model (JSmol)
  • C[C@@H]1CCN(CCN1C(=O)C2=C(C=CC(=C2)C)N3N=CC=N3)C4=NC5=C(O4)C=CC(=C5)Cl
  • InChI=1S/C23H23ClN6O2/c1-15-3-5-20(30-25-8-9-26-30)18(13-15)22(31)29-12-11-28(10-7-16(29)2)23-27-19-14-17(24)4-6-21(19)32-23/h3-6,8-9,13-14,16H,7,10-12H2,1-2H3/t16-/m1/s1 checkY
  • Key:JYTNQNCOQXFQPK-MRXNPFEDSA-N checkY
  (verify)

Suvorexant, sold under the brand name Belsomra, is an orexin antagonist medication which is used in the treatment of insomnia.[12][17] It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset and/or maintenance in adults.[12][17] Suvorexant helps with falling asleep faster, sleeping longer, being awake less in the middle of the night, and having better quality of sleep.[12][19] Its effectiveness is modest,[20] and is similar to that of other orexin antagonists, but is lower than that of benzodiazepines and Z-drugs.[21] Suvorexant is taken by mouth.[12][22][17]

Side effects of suvorexant include somnolence, daytime sleepiness and sedation, headache, dizziness, abnormal dreams, dry mouth, and impaired next-day driving ability.[12][19][23] Rarely, sleep paralysis, sleep-related hallucinations, complex sleep behaviors like sleepwalking, and suicidal ideation may occur.[12][17][20] Tolerance, dependence, withdrawal, and rebound effects do not appear to occur significantly with the medication.[12][24][25] Suvorexant is a dual orexin receptor antagonist (DORA).[17] It acts as a selective dual antagonist of the orexin OX1 and OX2 receptors.[17] The medication has an intermediate elimination half-life of 12 hours and a time to peak of about 2 to 3 hours.[12][17] Unlike benzodiazepines and Z-drugs, suvorexant does not interact with GABA receptors, instead having a distinct mechanism of action.[17][26]

Clinical development of suvorexant began in 2006[27] and it was introduced for medical use in 2014.[12][28] The medication is a schedule IV controlled substance in the United States and may have a modest potential for misuse.[29][12][30] In other places, such as Australia, suvorexant is a prescription-only medicine and is not a controlled drug.[11] Suvorexant is not available in generic formulations.[22][31][32] Besides suvorexant, other orexin receptor antagonists like lemborexant and daridorexant have also been introduced.[33][34]

Billy Preston & Syreeta
Studio album by
Released1981
StudioMotown/Hitsville U.S.A. Recording Studios (Los Angeles, California)
  • Amerycan Studios (North Hollywood, California),
  • Kendun Recorders (Burbank, California)
GenreR&B, Soul
LabelMotown
Producer

Billy Preston & Syreeta is a 1981 album of duets by Billy Preston and Syreeta released by Motown Records.[35] Six songs were produced by Ollie Brown, and four songs were produced and co-written by Michael Masser. An expanded version of the album with 10 songs and 7 bonus cuts was released on CD in late 2013 on SoulMusic Records.[36]

Shire of Gayndah
Queensland
Location within Queensland
Population2,911 (2006 census)[37]
 • Density1.07445/km2 (2.7828/sq mi)
Established1866
Area2,709.3 km2 (1,046.1 sq mi)
Council seatGayndah
RegionWide Bay–Burnett
WebsiteShire of Gayndah
LGAs around Shire of Gayndah:
Eisdvold Perry Biggenden
Mundubbera Shire of Gayndah Biggenden
Wondai Kilkivan Biggenden

The Shire of Gayndah was a local government area located in the northern catchment of the Burnett River, Queensland, Australia. The shire covered an area of 2,709.3 square kilometres (1,046.1 sq mi), and existed as a local government area from 1866 until 2008, when it amalgamated with several other shires to form the North Burnett Region.

Major activities in the shire included citrus production, beef and timber.

Wackbuilder

[edit]

Joseph Elias Wack
Personal details
Born
José Elias Vaque da Silva

(2001-05-14)May 14, 2001
Rio de Janeiro, Rio de Janeiro (state), Brazil
DiedNovember 28, 2022(2022-11-28) (aged 21)
London, UK
EducationWikimedia University

Joseph Elias Wack (May 14, 2001 - November 28, 2022) was a Brazilian author known for his online stories. Wack was shot dead while in London by "Spacebuilder" because he had exposed Spacebuilder as a pedophile.

MrLaffo
GenreSuperhero
Comedy
Trash
Based onMegamind
by Alan Schoolcraft
Brent Simons
Developed byAlan Schoolcraft
Brent Simons
Voices ofKeith Ferguson
Laura Post
Josh Brener
Maya Aoki Tuttle
Theme music composerAlex Seaver
Adam Lambert
Composers
  • Matthew Janszen
  • Bryan Winslow
No. of seasons1
No. of episodes16
Production
Executive producersEric Fogel
Alan Schoolcraft
Brent Simons
ProducerKelley Deer (episode 4–present)
Running time22 minutes
Production companyDreamWorks Animation Television
Original release
NetworkPeacock
ReleaseMarch 1, 2024 (2024-03-01)
Related
Megamind
Megamind vs. the Doom Syndicate

Megamind Rules! (originally titled Megamind's Guide to Defending Your City) is an American animated television series that is produced by DreamWorks Animation Television. The series is developed by Alan Schoolcraft and Brent Simons who created the characters based on the 2010 animated film Megamind, taking place after the events of its streaming sequel Megamind vs. the Doom Syndicate which follows Megamind learning to become a hero to Metro City while being an online influencer. It premiered alongside the film on Peacock on March 1, 2024.

Premise

[edit]

Picking up after the events of Megamind vs. the Doom Syndicate (2024), the series features Megamind defending Metro City with the help of his friends, Ol' Chum, Keiko, and newly elected Mayor, Roxanne.

Cast

[edit]

Main

[edit]
  • Keith Ferguson as Megamind, a blue, humanoid alien supervillain-turned-superhero with a large cranium. Ferguson replaces Will Ferrell from the first film, after previously voicing the character in the first film's tie-in video games.
  • Laura Post as Roxanne Ritchi, the mayor of Metro City (formerly a news reporter) who is Megamind's love interest. She temporary gains the powers of the Doom Syndicate when Machiavillain mind-controlled her to become evil. Post replaces Tina Fey from the first film.
  • Josh Brener as Ol' Chum (formerly Minion), a talking alien fish who has been Megamind's best friend and sidekick since childhood. He changed his name after a cease-and-desist from a fast food chain called Mr. Minion's Meatsicles. Brener replaces David Cross from the first film.
  • Maya Aoki Tuttle as Keiko Morita, Megamind's child fan, social media influencer, and Megamind's second sidekick.

Villains

[edit]
  • Adam Lambert as Machiavillain, Megamind's former mentor.
  • Lucie Pohl as Rochelle, a talking cockroach who is accidentally brought into existence due to Ol’ Chum's intelligence spray.
  • Brooke Dillman as Carla Magucci/Destruction Worker, a construction-themed supervillain. The character was one of the many scrapped villains that was planned to be in the first Megamind film. Destruction Worker (who was originally designed as male) was instead used in the video games Megamind: Ultimate Showdown and Megamind: Mega Team Unite.

Go Fish Gang

[edit]
  • Todd Haberkorn as Big King Fish, the leader of the Go Fish Gang.
  • Eric Murphy as Blue Mackerel, a member of the Go Fish Gang.
  • Joey Rudman as Red Snapper, a member of the Go Fish Gang.

The Doom Syndicate

[edit]
  • Emily Tunon as Lady Doppler, a storm-themed supervillain who can manipulate weather. She has her powers stolen.
  • Scott Adsit as Pierre Pressure, a mime-themed supervillain who has the power of hypnosis and speaks with a French accent. He is shown to speak with an American accent when his powers are stolen.
  • Talon Warburton as Lord Nighty-Knight (formerly Fright Knight), a knight-themed supervillain who can manipulate shadows. He is shown to be afraid of the dark when his powers are stolen.
  • Chris Sullivan as Behemoth, a lava golem. He is shown to be human-sized when his powers are stolen.

Supporting

[edit]
  • Roger Craig Smith as Jody Smelt, the cowardly former mayor of Metro City.
  • Jeanine Mason as Christina Christo, Roxanne's assistant who previously worked for Jody Smelt.
  • Max Mittelman as Dude Monkey, a monkey-themed social media influencer who attempts to overtake Megamind's internet popularity.
  • Tony Hale as Mel/Mr. Donut, the owner of a rundown diner turned donut shop.
  • Jeremy Jordan as Benett Schlurg-Peterman, Keiko's school teacher and an old friend of Roxanne.
  • Eric Fogel as Polly 227, a robot parakeet Megamind built for Ol' Chum.
  • Ross Marquand as Metro Man/Music Man, the former hero of Metro City who quit to begin a career in music. Marquand replaces Brad Pitt from the first film.
  • Jenny Yokobori as Blanche Morita, the mother of Keiko.
  • Haley Joel Osment as Dan Donner/Hu-Mouse, an employee of Everything City and scientist who gained the features and abilities of mice from a lab incident.
  • Natalia Del Riego as Terry Sasko/Supercool Power-Kid, a proclaimed rejected kid who is chosen by Machiavillain to have superpowers.

Guest

[edit]
  • John Lavelle as PAL-3000, a robot invented by Keiko that Megamind programs to become his best friend after he becomes jealous of Benett.

Episodes

[edit]

Pilot

[edit]
TitleDirected byWritten byStoryboarded byOriginal release date
"Megamind vs. the Doom Syndicate"Eric FogelAlan Schoolcraft and Brent SimonsDennis Crawford, Solomon Fong, Jason Horychun, Renee Howerton, Hadas Rosen, and Alejandra WiechersMarch 1, 2024 (2024-03-01)

Season 1 (2024)

[edit]
No.TitleDirected byWritten byStoryboarded byOriginal release date
1"Megamind vs. Dude Monkey"Joel DickieJD RyznarSolomon Fong and Renee HowertonMarch 1, 2024 (2024-03-01)
Megamind's popularity is challenged when a new superhero called Dude Monkey appears.
2"The Villainous Origin of Mr. Donut!"Mike WestAlan Schoolcraft and Brent SimonsSteve Garcia and Dennis CrawfordMarch 1, 2024 (2024-03-01)
Mr. Donut begins to turn villainous after he loses his memory.
3"Roach Hard: With a Vengeance"Mike WestEric FogelDennis Crawford and Steve GarciaMarch 1, 2024 (2024-03-01)
Chum accidentally causes a cockroach to become an anthropomorphic evil genius.
4"MegaMayor"Steve Garcia
Behzad Mansoori-Dara
Eric AcostaJason Horychun and Hadas RosenMarch 1, 2024 (2024-03-01)
Megamind and Roxanne try to act like each other when they accidentally switch bodies.
5"Extra Credit"Steve GarciaAnnabel SeymourSolomon Fong and Hadas RosenMarch 1, 2024 (2024-03-01)
Jealous of an old friend of Roxanne's, Megamind reprograms Keiko's robot into a new friend for himself.
6"Too Much Chum"Joel DickieEric AcostaShaan Khan, James Nguyen and David WiebeMarch 1, 2024 (2024-03-01)
An overworked Chum creates a clone of himself, but things go awry when the clone starts making more clones.
7"A Cake for Keiko"Mike WestJD RyznarDennis Crawford and Randy YoungMarch 1, 2024 (2024-03-01)
On her birthday, Keiko goes undercover in the Doom Syndicate team to prove to Megamind that she can be a hero.
8"Who Wants to Save a City?"Joel DickieAlan Schoolcraft and Brent SimonsShaan Khan, James Nguyen and David WiebeMarch 1, 2024 (2024-03-01)
Megamind's former mentor, Machiavillain returns.
9"Hero for a Day"[38]Steve GarciaAnnabel SeymourSolomon Fong and Hadas RosenJune 20, 2024 (2024-06-20)
With Metro City once again thinking that Megamind is a villain, he must make his way through town without being spotted; things become complicated when a plucky 7-year-old boy thinks he's the hero who can stop Megamind.
10"Of Mice That Are Men"[39]Mike WestEric AcostaDennis Crawford, Thalia Tomlinson, Ande Rose and Randy YoungJune 20, 2024 (2024-06-20)
In an effort to keep his finger on the pulse of Metro City, Megamind goes undercover as an ordinary sales clerk but soon learns there have been a series of robberies and disappearances in the store.
11"Game Over"[40]Joel DickieErica PetersonShaan Khan and David WiebeJune 20, 2024 (2024-06-20)
Machiavillain traps Megamind in a simulation designed to turn him evil again.
12"Blue Prison"[41]Steve GarciaJD RyznarSolomon Fong and Hadas RosenJune 20, 2024 (2024-06-20)
Megamind runs into his former nemesis Metro Man while trying to escape prison.
13"The Art of Destruction"[42]Joel DickieAnnabel SeymourShaan Khan and David WiebeJune 20, 2024 (2024-06-20)
Megamind swaps powers with Metro Man while fighting a new villain known as Destruction Worker.
14"Mission: Machia-fest"[43]Mike WestEric AcostaDennis Crawford and Thalia TomlinsonJune 20, 2024 (2024-06-20)
Megamind, Chum and the rest of the team attempt to infiltrate a festival thrown by Machiavillain to expose him as a villain to the rest of the city.
15"Villain City"[44]Mike WestAnnabel SeymourDennis Crawford and Thalia TomlinsonJune 20, 2024 (2024-06-20)
After Machiavillain mind-controls the citizens of Metro City, it's up to Megamind and Keiko to find a way to cure them all.
16"Thrilling Conclusions!"[45]Steve GarciaAlan Schoolcraft and Brent SimonsSolomon Fong and Hadas RosenJune 20, 2024 (2024-06-20)
Megamind faces the ultimate challenge when he must square off against a mind-controlled Roxanne.

Production

[edit]

On February 11, 2022, it was announced that Peacock had ordered a CG animated series from DreamWorks Animation Television serving as a follow up to the film, originally titled Megamind's Guide to Defending Your City. The series chronicles the new hero's quest to become a social media influencer and a true superhero. The original writers of the film, Alan Schoolcraft and Brent Simons, are signed on as executive producers and showrunners, with Celebrity Deathmatch creator Eric Fogel also being an executive producer. JD Ryznar was co-executive producer and story editor.[46]

On August 5, 2022, Simons confirmed that the show's writing was completed, and production was moving forward.[47] In January 2023, it was revealed that the series would be released in 2024.[48] In February 2024, it was announced that the series, now titled Megamind Rules! would be released on March 1, 2024. Keith Ferguson, Laura Post, Josh Brener, Maya Aoki Tuttle, Emily Tunon, Talon Warburton, Scott Adsit, Chris Sullivan, Tony Hale, Jeanine Mason and Adam Lambert were announced as part of the cast.[49]

New episodes of the show began streaming on June 20, 2024.[50]

References

[edit]
  1. ^ "Jewish Women's Archive. "Laura Moser"". Retrieved 17 June 2017.
  2. ^ "Megamind Rules!: Season 1, Episode 10 | Rotten Tomatoes". Rotten Tomatoes.
  3. ^ "Megamind Rules!: Season 1, Episode 11 | Rotten Tomatoes". Rotten Tomatoes.
  4. ^ "Megamind Rules!: Season 1, Episode 12 | Rotten Tomatoes". Rotten Tomatoes.
  5. ^ "Megamind Rules!: Season 1, Episode 13 | Rotten Tomatoes". Rotten Tomatoes.
  6. ^ "Megamind Rules!: Season 1, Episode 14 | Rotten Tomatoes". Rotten Tomatoes.
  7. ^ "Megamind Rules!: Season 1, Episode 15 | Rotten Tomatoes". Rotten Tomatoes.
  8. ^ "Megamind Rules!: Season 1, Episode 16 | Rotten Tomatoes". Rotten Tomatoes.
  9. ^ Del Rosario, Alexandra (11 February 2022). "Peacock Bolsters Animated Kids Programming Slate With 'Megamind,' 'Abomianble' Series & More". Deadline. Archived from the original on 11 February 2022. Retrieved 9 March 2024.
  10. ^ Simons, Brent (5 August 2022). "MEGAMIND'S writer room is wrapping up today as production moves forward. If you're looking for some wonderfully talented and amazing people to join writing your staff, @alanfofalan and I got some dynamite recommendations. Hit us up!". Twitter. Archived from the original on 2 October 2022. Retrieved 9 March 2024.
  11. ^ a b Cite error: The named reference Belsomra-AU-Label was invoked but never defined (see the help page).
  12. ^ a b c d e f g h i j k l m n o p q r s t "Belsomra- suvorexant tablet, film coated". DailyMed. Retrieved 30 January 2020.
  13. ^ Cite error: The named reference Drugs.com-Pregnancy was invoked but never defined (see the help page).
  14. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  15. ^ "Search Page - Drug and Health Product Register". 23 October 2014.
  16. ^ a b Cite error: The named reference MerckSharpDohme2013 was invoked but never defined (see the help page).
  17. ^ a b c d e f g h i Jacobson LH, Callander GE, Hoyer D (November 2014). "Suvorexant for the treatment of insomnia". Expert Review of Clinical Pharmacology. 7 (6): 711–730. doi:10.1586/17512433.2014.966813. PMID 25318834. S2CID 41099462.
  18. ^ Cite error: The named reference DimovaBrarMen2014 was invoked but never defined (see the help page).
  19. ^ a b Cite error: The named reference pmid28365447 was invoked but never defined (see the help page).
  20. ^ a b Cite error: The named reference pmid26648692 was invoked but never defined (see the help page).
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  22. ^ a b Cite error: The named reference Drugs.com-Belsomra-Generic was invoked but never defined (see the help page).
  23. ^ Kishi T, Matsunaga S, Iwata N (2015). "Suvorexant for Primary Insomnia: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials". PLOS ONE. 10 (8): e0136910. Bibcode:2015PLoSO..1036910K. doi:10.1371/journal.pone.0136910. PMC 4552781. PMID 26317363.
  24. ^ Cite error: The named reference pmid28994603 was invoked but never defined (see the help page).
  25. ^ Cite error: The named reference pmid32901578 was invoked but never defined (see the help page).
  26. ^ Atkin T, Comai S, Gobbi G (April 2018). "Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery". Pharmacological Reviews. 70 (2): 197–245. doi:10.1124/pr.117.014381. PMID 29487083. S2CID 3578916.
  27. ^ Cite error: The named reference pmid25406050 was invoked but never defined (see the help page).
  28. ^ Cite error: The named reference APDNews2014 was invoked but never defined (see the help page).
  29. ^ Cite error: The named reference FederalRegister2016 was invoked but never defined (see the help page).
  30. ^ Cite error: The named reference pmid25231363 was invoked but never defined (see the help page).
  31. ^ Cite error: The named reference pmid30092886 was invoked but never defined (see the help page).
  32. ^ Cite error: The named reference pmid26955275 was invoked but never defined (see the help page).
  33. ^ Cite error: The named reference pmid35043499 was invoked but never defined (see the help page).
  34. ^ Cite error: The named reference pmid35298826 was invoked but never defined (see the help page).
  35. ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta, LP 1981
  36. ^ discogs: Billy Preston & Syreeta – Billy Preston & Syreeta (Expanded CD Edition)
  37. ^ Australian Bureau of Statistics (25 October 2007). "Gayndah (S) (Local Government Area)". 2006 Census QuickStats. Retrieved 18 March 2008.
  38. ^ "Megamind Rules!: Season 1, Episode 9 | Rotten Tomatoes". Rotten Tomatoes.
  39. ^ "Megamind Rules!: Season 1, Episode 10 | Rotten Tomatoes". Rotten Tomatoes.
  40. ^ "Megamind Rules!: Season 1, Episode 11 | Rotten Tomatoes". Rotten Tomatoes.
  41. ^ "Megamind Rules!: Season 1, Episode 12 | Rotten Tomatoes". Rotten Tomatoes.
  42. ^ "Megamind Rules!: Season 1, Episode 13 | Rotten Tomatoes". Rotten Tomatoes.
  43. ^ "Megamind Rules!: Season 1, Episode 14 | Rotten Tomatoes". Rotten Tomatoes.
  44. ^ "Megamind Rules!: Season 1, Episode 15 | Rotten Tomatoes". Rotten Tomatoes.
  45. ^ "Megamind Rules!: Season 1, Episode 16 | Rotten Tomatoes". Rotten Tomatoes.
  46. ^ Del Rosario, Alexandra (11 February 2022). "Peacock Bolsters Animated Kids Programming Slate With 'Megamind,' 'Abomianble' Series & More". Deadline. Archived from the original on 11 February 2022. Retrieved 9 March 2024.
  47. ^ Simons, Brent (5 August 2022). "MEGAMIND'S writer room is wrapping up today as production moves forward. If you're looking for some wonderfully talented and amazing people to join writing your staff, @alanfofalan and I got some dynamite recommendations. Hit us up!". Twitter. Archived from the original on 2 October 2022. Retrieved 9 March 2024.
  48. ^ "Megamind television series print ad (page 57)". Kidscreen (February/March 2023). 24 January 2023. Archived from the original on 3 March 2023. Retrieved 9 March 2024.
  49. ^ Milligan, Mercedes. "Trailer: DreamWorks' 'Megamind' Returns in New Peacock Film & Series". www.animationmagazine.net. Retrieved 9 March 2024.
  50. ^ Rozenboom, Amanda (3 June 2024). "Here Is Every TV Series Coming to Peacock in June 2024". MovieWeb. Retrieved 8 June 2024.
[edit]