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Micropolygyeria

a.    Polymicrogyria is one of the most common malformations of cortical development

History

a. Different inheritance patterens of isolated polymicrogyria have been discovered and observed for more information over time

Clinical Charactistics

a. Polymicrogyria is characterized by stable neurologic deficits

Functions

a. Several forms of the condition have an autosomal recessive pattern of inheritance

b. Functional studies of the GPR56 gene product will yield insights not only into the causes of polymicrogyria but also into the mechanisms of normal cortical development and the regional patterning of the cerebral cortex

Pathology

a. GPR56-related bilateral frontoparietal polymicrogyria has a confirmed genetic cause; it is inherited in an autosomal recessive manner

Diagnostic/Testing

a. The diagnosis is typically made by magnetic resonance imaging (MRI) that reveals either irregularity to the cortical surface suggestive of multiple small folds or an irregular, scalloped appearance of the gray matter-white matter junction

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872023/figure/Fig1/References

Secondary References

http://www.ncbi.nlm.nih.gov/pubmed/20301504

http://www.ncbi.nlm.nih.gov/pubmed/20198472

http://www.ncbi.nlm.nih.gov/pubmed/15863665

http://www.ncbi.nlm.nih.gov/pubmed/23001883