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USP8

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USP8
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesUSP8, HumORF8, SPG59, UBPY, ubiquitin specific peptidase 8, PITA4
External IDsOMIM: 603158; MGI: 1934029; HomoloGene: 3782; GeneCards: USP8; OMA:USP8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001128610
NM_001128611
NM_001283049
NM_005154

NM_001252580
NM_019729

RefSeq (protein)

NP_001122082
NP_001269978
NP_005145

NP_001239509
NP_062703

Location (UCSC)Chr 15: 50.42 – 50.51 MbChr 2: 126.55 – 126.6 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ubiquitin carboxyl-terminal hydrolase 8 is an enzyme that in humans is encoded by the USP8 gene.[5][6][7]

Interactions

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USP8 has been shown to interact with RNF41[8] and STAM2.[9][10]

Diseases

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In a few cases of Morbus Cushing's disease, a mutation of USP8 has been found.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000138592Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027363Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Puente XS, Sánchez LM, Overall CM, López-Otín C (July 2003). "Human and mouse proteases: a comparative genomic approach". Nature Reviews. Genetics. 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. S2CID 2856065.
  6. ^ Janssen JW, Schleithoff L, Bartram CR, Schulz AS (April 1998). "An oncogenic fusion product of the phosphatidylinositol 3-kinase p85beta subunit and HUMORF8, a putative deubiquitinating enzyme". Oncogene. 16 (13): 1767–72. doi:10.1038/sj.onc.1201695. PMID 9582025.
  7. ^ "Entrez Gene: USP8 ubiquitin specific peptidase 8".
  8. ^ Wu X, Yen L, Irwin L, Sweeney C, Carraway KL (September 2004). "Stabilization of the E3 ubiquitin ligase Nrdp1 by the deubiquitinating enzyme USP8". Molecular and Cellular Biology. 24 (17): 7748–57. doi:10.1128/MCB.24.17.7748-7757.2004. PMC 506982. PMID 15314180.
  9. ^ Kaneko T, Kumasaka T, Ganbe T, Sato T, Miyazawa K, Kitamura N, Tanaka N (November 2003). "Structural insight into modest binding of a non-PXXP ligand to the signal transducing adaptor molecule-2 Src homology 3 domain". The Journal of Biological Chemistry. 278 (48): 48162–8. doi:10.1074/jbc.M306677200. PMID 13129930.
  10. ^ Kato M, Miyazawa K, Kitamura N (December 2000). "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I)(D/N)RXXKP". The Journal of Biological Chemistry. 275 (48): 37481–7. doi:10.1074/jbc.M007251200. PMID 10982817.

Further reading

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