Tyrosine—arginine ligase
(Redirected from Tyrosine-arginine ligase)
| Tyrosine—arginine ligase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 6.3.2.24 | ||||||||
| CAS no. | 116036-78-3 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a tyrosine—arginine ligase (EC 6.3.2.24) is an enzyme that catalyzes the chemical reaction
- ATP + L-tyrosine + L-arginine AMP + diphosphate + L-tyrosyl-L-arginine
The 3 substrates of this enzyme are ATP, L-tyrosine, and L-arginine, whereas its 3 products are AMP, diphosphate, and L-tyrosyl-L-arginine.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is L-tyrosine:L-arginine ligase (AMP-forming). Other names in common use include tyrosyl-arginine synthase, kyotorphin synthase, kyotorphin-synthesizing enzyme, and kyotorphin synthetase.
References
[edit]- Ueda H, Yoshihara Y, Fukushima N, Shiomi H, Nakamura A, Takagi H (June 1987). "Kyotorphin (tyrosine-arginine) synthetase in rat brain synaptosomes". The Journal of Biological Chemistry. 262 (17): 8165–73. PMID 3597366.
