TBC1D10A

TBC1D10A
Identifiers
Aliases	TBC1D10A, EPI64, TBC1D10, dJ130H16.1, dJ130H16.2, TBC1 domain family member 10A
External IDs	OMIM: 610020; MGI: 2144164; HomoloGene: 32762; GeneCards: TBC1D10A; OMA:TBC1D10A - orthologs
Gene location (Human)
Chr.	Chromosome 22 (human)
End	30,326,947 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	4,165,505 bp
RNA expression pattern
	Top expressed in
	nasal epithelium; ; skin of arm; ; skin of leg; ; mucosa of esophagus; ; skin of abdomen; ; granulocyte; ; gingival epithelium; ; mucosa of transverse colon; ; ascending aorta; ; spleen;
	Top expressed in
	lip; ; right kidney; ; gastrula; ; yolk sac; ; molar; ; spermatocyte; ; esophagus; ; proximal tubule; ; corneal stroma; ; spermatid;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PDZ domain binding; protein binding; guanyl-nucleotide exchange factor activity; GTPase activator activity; cadherin binding;
Cellular component	microvillus; plasma membrane; cell projection; extracellular exosome; endomembrane system; cytosol; intracellular anatomical structure;
Biological process	regulation of cilium assembly; activation of cysteine-type endopeptidase activity; retrograde transport, endosome to Golgi; positive regulation of proteolysis; activation of GTPase activity; regulation of vesicle fusion; intracellular protein transport;
	Sources:Amigo / QuickGO
Orthologs
	83874
	103724
	ENSG00000099992
	ENSMUSG00000034412
	Q9BXI6
	P58802
	NM_031937; NM_001204240
	NM_134023
	NP_001191169; NP_114143; NP_001191169.1; NP_114143.1
	NP_598784
	Wikidata
View/Edit Human	View/Edit Mouse

TBC1 domain family member 10A is a protein that in humans is encoded by the TBC1D10A gene.^[5]^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000099992 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000034412 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Reczek D, Bretscher A (Apr 2001). "Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP". J Cell Biol. 153 (1): 191–206. doi:10.1083/jcb.153.1.191. PMC 2185518. PMID 11285285.
^ "Entrez Gene: TBC1D10A TBC1 domain family, member 10A".

Sanger Centre, The; Washington University Genome Sequencing Cente, The (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
Kapranov P, Drenkow J, Cheng J, et al. (2005). "Examples of the complex architecture of the human transcriptome revealed by RACE and high-density tiling arrays". Genome Res. 15 (7): 987–97. doi:10.1101/gr.3455305. PMC 1172043. PMID 15998911.
Itoh T, Fukuda M (2006). "Identification of EPI64 as a GTPase-activating protein specific for Rab27A". J. Biol. Chem. 281 (42): 31823–31. doi:10.1074/jbc.M603808200. PMID 16923811.
Hanono A, Garbett D, Reczek D, et al. (2007). "EPI64 regulates microvillar subdomains and structure". J. Cell Biol. 175 (5): 803–13. doi:10.1083/jcb.200604046. PMC 2064679. PMID 17145964.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000099992 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000034412 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11285285-5] Reczek D, Bretscher A (Apr 2001). "Identification of EPI64, a TBC/rabGAP domain-containing microvillar protein that binds to the first PDZ domain of EBP50 and E3KARP". J Cell Biol. 153 (1): 191–206. doi:10.1083/jcb.153.1.191. PMC 2185518. PMID 11285285.

[entrez-6] "Entrez Gene: TBC1D10A TBC1 domain family, member 10A".

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References

Further reading