Talk:Kindling (sedative–hypnotic withdrawal)

Neuroscience Mid‑importance

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Making a start on this article

This subject matter is getting quite a lot of research attention in recent years, especially in relation to alcohol withdrawal. A couple of alcohol articles and a benzo article have some technical detail (probably too much technical detail for the avergae reader) on this subject matter; so some of it needs to be moved over to this article I feel. Please do not nominate for deletion this page, but allow it to sit for a week or two to give me a chance to build it up to a more substantial article (I know that it is very basic but that is because it is a start on an article :=]). Thanks. :)--Literaturegeek | T@1k? 23:34, 28 August 2010 (UTC)[reply]

Barbiturates

Barbs should be mentioned somewhere, too. They are tougher than benzos.Miacek (talk) 16:53, 12 May 2018 (UTC)[reply]

Original Research

This article seems like it's an example of original research. As a simple heuristic, consider how none of the sources in the article (not one) has the word "kindling" in its title. I've searched scientific articles for the topic of kindling myself, finding nothing. It seems like the topic is known only by users of GABAergics on forum boards and by only this article. If this were an actual phenomenon, there would be reviews on the topic with titles like, "Kindling in GABAergics," that spend tens of pages going deeply into the topic based on all the available evidence. If a review like this existed, it'd be the synthesis / research from a qualified mind on the topic (still possibly incorrect, depending on the strength of the evidence), and it'd make this article not be the synthesis / research of some random person that uses Wikipedia. This article has confused many, many people to whom it affects vastly like people prescribed GABAergics, people who drink alcohol, and people who illicitly use GABAergics. I've seen a reference to this page many times when I show doubt that kindling is a thing, because it's the only place on the entire internet outside of forum posts that claims that this potential phenomenon is real. Please, stop doing more harm than good with your original research by deleting this article. Stop presenting the weakly glued together concepts of unrelated reviews and studies as a justification, through original research, that kindling is real. Here's another embarrassingly wrong thing about this post - the introductory paragraphs have ZERO citations, and that's the part of this article that definitively asserts kindling is real rather than talking about alcohol use in adolescents, citing some random study about it. If I had to guess, I'd say this article has survived this long, because most Wikipedia editors aren't drug users and the phrase "kindling in GABAergics" is basically only used in forums that discuss recreational and often illicit use of GABAergics. — Preceding unsigned comment added by 96.60.253.17 (talk • contribs) 09:03, 25 July 2021 (UTC)[reply]

There has been research about this subject. See, e.g.,

Pius, Charlene; Maloba, Margaret (January 2010). "Towards evidence based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 3: chlordiazepoxide, the management of alcohol withdrawal and the kindling effect". Emergency medicine journal: EMJ. 27 (1): 56–57. doi:10.1136/emj.2009.087528. ISSN 1472-0213. PMID 20029013.
Olsen, Richard W.; Spigelman, Igor (2012), Noebels, Jeffrey L.; Avoli, Massimo; Rogawski, Michael A.; Olsen, Richard W. (eds.), "GABAA Receptor Plasticity in Alcohol Withdrawal", Jasper's Basic Mechanisms of the Epilepsies (4th ed.), Bethesda (MD): National Center for Biotechnology Information (US), PMID 22787640, retrieved 2021-08-04
Framer, Adele (2021-03-16). "What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications". Therapeutic Advances in Psychopharmacology. 11. doi:10.1177/2045125321991274. ISSN 2045-1253. PMC 7970174. PMID 33796265.(especially the section titled "The pitfalls of hyper-reactivity and kindling reactions")

It also appears in professional reference works and similar books, such as:

Miller, Shannon (2018-11-26). The ASAM Principles of Addiction Medicine. Lippincott Williams & Wilkins. ISBN 978-1-4963-7100-3.
Biological Research on Addiction: Comprehensive Addictive Behaviors and Disorders, Volume 2. Academic Press. 2013-05-17. p. 220. ISBN 978-0-12-398360-2. (which calls it a "well-substantiated theory")

Also, it is normal for introductory paragraphs to have no citations in Wikipedia articles; see WP:LEADCITE for the official advice. WhatamIdoing (talk) 05:49, 4 August 2021 (UTC)[reply]