From Wikipedia, the free encyclopedia
Protein-coding gene in the species Homo sapiens
Transcription termination factor 2 is a protein that in humans is encoded by the TTF2 gene .[ 5] [ 6]
This gene encodes a member of the SWI2/SNF2 family of proteins, which play a critical role in altering protein-DNA interactions. The encoded protein has been shown to have dsDNA-dependent ATPase activity and RNA polymerase II termination activity. This protein interacts with cell division cycle 5-like, associates with human splicing complexes, and plays a role in pre-mRNA splicing.[ 6]
TTF2 has been shown to interact with CDC5L .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000116830 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033222 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Liu M, Xie Z, Price DH (October 1998). "A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member" . The Journal of Biological Chemistry . 273 (40): 25541–4. doi :10.1074/jbc.273.40.25541 PMID 9748214 . ^ a b "Entrez Gene: TTF2 transcription termination factor, RNA polymerase II" .^ Leonard D, Ajuh P, Lamond AI, Legerski RJ (September 2003). "hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing". Biochemical and Biophysical Research Communications . 308 (4): 793–801. CiteSeerX 10.1.1.539.8359 doi :10.1016/S0006-291X(03)01486-4 . PMID 12927788 .
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