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TRIM27

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TRIM27
Identifiers
AliasesTRIM27, RFP, RNF76, tripartite motif containing 27
External IDsOMIM: 602165; MGI: 97904; HomoloGene: 111010; GeneCards: TRIM27; OMA:TRIM27 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_030950
NM_006510

NM_009054

RefSeq (protein)

NP_006501

NP_033080

Location (UCSC)Chr 6: 28.9 – 28.92 MbChr 13: 21.36 – 21.38 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Zinc finger protein RFP is a protein that in humans is encoded by the TRIM27 gene.[5][6]

This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nuclear matrix. It interacts with the enhancer of polycomb protein and represses gene transcription. It is also thought to be involved in the differentiation of male germ cells. Fusion of the N-terminus of this protein with the truncated C-terminus of the RET gene product has been shown to result in production of the ret transforming protein.[6]

Interactions

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TRIM27 has been shown to interact with PRAM1[7] and EIF3S6.[8]

References

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  1. ^ a b c ENSG00000233948, ENSG00000204713, ENSG00000215641, ENSG00000237071, ENSG00000237462, ENSG00000234495 GRCh38: Ensembl release 89: ENSG00000229006, ENSG00000233948, ENSG00000204713, ENSG00000215641, ENSG00000237071, ENSG00000237462, ENSG00000234495Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021326Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vernet C, Boretto J, Mattei MG, Takahashi M, Jack LJ, Mather IH, Rouquier S, Pontarotti P (Mar 1994). "Evolutionary study of multigenic families mapping close to the human MHC class I region". J Mol Evol. 37 (6): 600–12. Bibcode:1993JMolE..37..600V. doi:10.1007/bf00182746. PMID 8114113. S2CID 19054302.
  6. ^ a b "Entrez Gene: TRIM27 tripartite motif-containing 27".
  7. ^ Cao, T; Duprez E; Borden K L; Freemont P S; Etkin L D (May 1998). "Ret finger protein is a normal component of PML nuclear bodies and interacts directly with PML". J. Cell Sci. 111 (10). ENGLAND: 1319–29. doi:10.1242/jcs.111.10.1319. ISSN 0021-9533. PMID 9570750.
  8. ^ Morris-Desbois, C; Bochard V; Reynaud C; Jalinot P (Oct 1999). "Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies". J. Cell Sci. 112 (19). ENGLAND: 3331–42. doi:10.1242/jcs.112.19.3331. ISSN 0021-9533. PMID 10504338.

Further reading

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