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TRERF1

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TRERF1
Identifiers
AliasesTRERF1, BCAR2, HSA277276, RAPA, TREP132, TReP-132, dJ139D8.5, transcriptional regulating factor 1
External IDsOMIM: 610322; MGI: 2442086; HomoloGene: 14129; GeneCards: TRERF1; OMA:TRERF1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001097623
NM_172622

RefSeq (protein)

NP_001284502
NP_277037

NP_001091092
NP_766210

Location (UCSC)Chr 6: 42.22 – 42.45 MbChr 17: 47.45 – 47.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.[5][6]

This gene encodes a zinc-finger transcriptional regulating protein that interacts with CBP/p300 to regulate the human gene CYP11A1.[6]

Interactions

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TRERF1 has been shown to interact with Steroidogenic factor 1,[7] EP300[5] and CREB-binding protein.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000124496Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000064043Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). "A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression". The Journal of Biological Chemistry. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124.
  6. ^ a b "Entrez Gene: TRERF1 transcriptional regulating factor 1".
  7. ^ Gizard F, Lavallee B, DeWitte F, Teissier E, Staels B, Hum DW (October 2002). "The transcriptional regulating protein of 132 kDa (TReP-132) enhances P450scc gene transcription through interaction with steroidogenic factor-1 in human adrenal cells". The Journal of Biological Chemistry. 277 (42): 39144–55. doi:10.1074/jbc.M205786200. PMID 12101186.

Further reading

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