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TPD52L2

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TPD52L2
Identifiers
AliasesTPD52L2, D54, TPD54, tumor protein D52 like 2, TPD52 like 2
External IDsOMIM: 603747; MGI: 1913564; HomoloGene: 2469; GeneCards: TPD52L2; OMA:TPD52L2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)
RefSeq (protein)
Location (UCSC)Chr 20: 63.87 – 63.89 MbChr 2: 181.14 – 181.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Tumor protein D54 is a protein that in humans is encoded by the TPD52L2 gene.[5][6]

Interactions

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TPD52L2 has been shown to interact with TPD52L1[5] and TPD52.[5]

Cellular function

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TPD52L2 has a role in membrane traffic.[7] TPD52L2 is found on small transport vesicles, termed intracellular nanovesicles, that transfer proteins between different cellular compartments. When TPD52L2 is depleted from HeLa cells, the following trafficking pathways are impaired: anterograde traffic, recycling of cargo and Golgi integrity.[7] Proteomic analysis indicates that TPD52L2 is one of the most abundant proteins expressed in HeLa cells.[8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101150Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000827Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Byrne JA, Nourse CR, Basset P, Gunning P (Mar 1998). "Identification of homo- and heteromeric interactions between members of the breast carcinoma-associated D52 protein family using the yeast two-hybrid system". Oncogene. 16 (7): 873–81. doi:10.1038/sj.onc.1201604. PMID 9484778. S2CID 9948136.
  6. ^ "Entrez Gene: TPD52L2 tumor protein D52-like 2".
  7. ^ a b Larocque G, La-Borde PJ, Clarke NI, Carter NJ, Royle SJ (2019). "Tumor protein D54 defines a new class of intracellular transport vesicle". J Cell Biol. 219 (1). doi:10.1083/jcb.201812044. PMC 7039206. PMID 31672706.
  8. ^ Hein MY, Hubner NC, Poser I, Cox J, Nagaraj N, Toyoda Y, Gak IA, Weisswange I, Mansfeld J, Buchholz F, Hyman AA, Mann M (2017). "A human interactome in three quantitative dimensions organized by stoichiometries and abundances". Cell. 163 (3): 712–23. doi:10.1016/j.cell.2015.09.053. PMID 26496610.

Further reading

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