SNAPC4

SNAPC4
Identifiers
Aliases	SNAPC4, PTFalpha, SNAP190, small nuclear RNA activating complex polypeptide 4
External IDs	OMIM: 602777; MGI: 2443935; HomoloGene: 2321; GeneCards: SNAPC4; OMA:SNAPC4 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	136,400,176 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	26,270,665 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; endothelial cell; ; right uterine tube; ; paraflocculus of cerebellum; ; right testis; ; left testis; ; right hemisphere of cerebellum; ; frontal pole; ; pancreatic ductal cell; ; nasal epithelium;
	Top expressed in
	superior frontal gyrus; ; neural layer of retina; ; primary visual cortex; ; tail of embryo; ; genital tubercle; ; lumbar subsegment of spinal cord; ; spermatocyte; ; yolk sac; ; ventricular zone; ; cerebellar cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA-binding transcription factor activity; DNA binding; sequence-specific DNA binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	nucleus; nucleoplasm; snRNA-activating protein complex;
Biological process	regulation of transcription, DNA-templated; transcription by RNA polymerase II; transcription, DNA-templated; snRNA transcription by RNA polymerase III; transcription by RNA polymerase III; regulation of transcription by RNA polymerase II; snRNA transcription by RNA polymerase II; cell differentiation; snRNA transcription;
	Sources:Amigo / QuickGO
Orthologs
	6621
	227644
	ENSG00000165684
	ENSMUSG00000036281
	Q5SXM2
	Q8BP86
	NM_003086; NM_001394201; NM_001394202; NM_001394203
	NM_001290419; NM_172339
	NP_003077
NP_001277348; NP_758842; NP_001393660; NP_001393661; NP_001393662;
	NP_001393663; NP_001393664; NP_001393665; NP_001393666; NP_001393667; NP_001393668
	Wikidata
View/Edit Human	View/Edit Mouse

snRNA-activating protein complex subunit 4 is a protein that in humans is encoded by the SNAPC4 gene.^[5]^[6]

Interactions

SNAPC4 has been shown to interact with SNAPC1,^[7] POU2F1^[5]^[8] and SNAPC2.^[5]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000165684 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000036281 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b ^c Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.
^ "Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa".
^ ^a ^b Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
^ Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. Bibcode:2002AcCrD..58..511H. doi:10.1107/S0907444901021461. PMID 11856838.

Henry RW, Sadowski CL, Kobayashi R, Hernandez N (April 1995). "A TBP-TAF complex required for transcription of human snRNA genes by RNA polymerase II and III". Nature. 374 (6523): 653–6. Bibcode:1995Natur.374..653H. doi:10.1038/374653a0. PMID 7715707. S2CID 4325527.
Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.
Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. Bibcode:2002AcCrD..58..511H. doi:10.1107/S0907444901021461. PMID 11856838.
Hinkley CS, Hirsch HA, Gu L, LaMere B, Henry RW (May 2003). "The small nuclear RNA-activating protein 190 Myb DNA binding domain stimulates TATA box-binding protein-TATA box recognition". The Journal of Biological Chemistry. 278 (20): 18649–57. doi:10.1074/jbc.M204247200. PMID 12621023.
Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Gu L, Esselman WJ, Henry RW (July 2005). "Cooperation between small nuclear RNA-activating protein complex (SNAPC) and TATA-box-binding protein antagonizes protein kinase CK2 inhibition of DNA binding by SNAPC". The Journal of Biological Chemistry. 280 (30): 27697–704. doi:10.1074/jbc.M503206200. PMID 15955816.
Gu L, Husain-Ponnampalam R, Hoffmann-Benning S, Henry RW (September 2007). "The protein kinase CK2 phosphorylates SNAP190 to negatively regulate SNAPC DNA binding and human U6 transcription by RNA polymerase III". The Journal of Biological Chemistry. 282 (38): 27887–96. doi:10.1074/jbc.M702269200. PMID 17670747.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000165684 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000036281 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9418884-5] Wong MW, Henry RW, Ma B, Kobayashi R, Klages N, Matthias P, Strubin M, Hernandez N (January 1998). "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Molecular and Cellular Biology. 18 (1): 368–77. doi:10.1128/mcb.18.1.368. PMC 121507. PMID 9418884.

[entrez-6] "Entrez Gene: SNAPC4 small nuclear RNA activating complex, polypeptide 4, 190kDa".

[pmid11056176-7] Ma B, Hernandez N (February 2001). "A map of protein-protein contacts within the small nuclear RNA-activating protein complex SNAPc". The Journal of Biological Chemistry. 276 (7): 5027–35. doi:10.1074/jbc.M009301200. PMID 11056176.

[pmid11856838-8] Hovde S, Brooks A, Strong K, Geiger JH (March 2002). "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallographica Section D. 58 (Pt 3): 511–2. Bibcode:2002AcCrD..58..511H. doi:10.1107/S0907444901021461. PMID 11856838.

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Interactions

References

Further reading