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Protein-coding gene in the species Homo sapiens
Exocyst complex component 2 is a protein that in humans is encoded by the EXOC2 gene .[ 5] [ 6] [ 7]
The protein encoded by this gene is a component of the exocyst complex , a multiple protein complex essential for targeting exocytic vesicles to specific docking sites on the plasma membrane. Though best characterized in yeast , the component proteins and the functions of the exocyst complex have been demonstrated to be highly conserved in higher eukaryotes. At least eight components of the exocyst complex, including this protein, are found to interact with the actin cytoskeletal remodeling and vesicle transport machinery. This interaction has been shown to mediate filopodia formation in fibroblasts .[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000112685 – Ensembl , May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021357 – Ensembl , May 2017^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .^ Murthy M, Garza D, Scheller RH, Schwarz TL (Feb 2003). "Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists" . Neuron . 37 (3): 433–47. doi :10.1016/S0896-6273(03)00031-X PMID 12575951 . S2CID 14351315 . ^ Sjolinder M, Uhlmann J, Ponstingl H (Dec 2002). "DelGEF, a homologue of the Ran guanine nucleotide exchange factor RanGEF, binds to the exocyst component Sec5 and modulates secretion" . FEBS Lett . 532 (1–2): 211–5. doi :10.1016/S0014-5793(02)03677-3 PMID 12459492 . S2CID 31552100 . ^ a b "Entrez Gene: EXOC2 exocyst complex component 2" .
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