SGPP1

SGPP1
Identifiers
Aliases	SGPP1, SPPase1, sphingosine-1-phosphate phosphatase 1, SPP-1
External IDs	OMIM: 612826; MGI: 2135760; HomoloGene: 101696; GeneCards: SGPP1; OMA:SGPP1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	63,728,065 bp
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	75,782,503 bp
RNA expression pattern
	Top expressed in
	lymph node; ; placenta; ; islet of Langerhans; ; C1 segment; ; endometrium; ; human kidney; ; right lobe of liver; ; Brodmann area 9; ; Achilles tendon; ; prefrontal cortex;
	Top expressed in
	seminal vesicula; ; lobe of prostate; ; decidua; ; lacrimal gland; ; gastrula; ; skin of abdomen; ; proximal tubule; ; parotid gland; ; right kidney; ; gastric mucosa;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; sphingosine-1-phosphate phosphatase activity; dihydrosphingosine-1-phosphate phosphatase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane; plasma membrane; nucleus; nucleoplasm;
Biological process	intrinsic apoptotic signaling pathway; sphingosine metabolic process; sphingolipid biosynthetic process; extrinsic apoptotic signaling pathway; dephosphorylation; sphinganine-1-phosphate metabolic process; sphingolipid metabolic process; ER to Golgi ceramide transport; regulation of keratinocyte differentiation; regulation of epidermis development;
	Sources:Amigo / QuickGO
Orthologs
	81537
	81535
	ENSG00000126821; ENSG00000285281
	ENSMUSG00000021054
	Q9BX95
	Q9JI99
	NM_030791
	NM_030750
	NP_110418
	NP_109675
	Wikidata
View/Edit Human	View/Edit Mouse

Sphingosine-1-phosphate phosphatase 1 is an enzyme that in humans is encoded by the SGPP1 gene.^[5]^[6]

References

^ ^a ^b ^c ENSG00000285281 GRCh38: Ensembl release 89: ENSG00000126821, ENSG00000285281 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021054 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (Aug 2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death". Proc Natl Acad Sci U S A. 97 (14): 7859–64. Bibcode:2000PNAS...97.7859M. doi:10.1073/pnas.120146897. PMC 16635. PMID 10859351.
^ "Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1".

Ogawa C, Kihara A, Gokoh M, Igarashi Y (2003). "Identification and characterization of a novel human sphingosine-1-phosphate phosphohydrolase, hSPP2". J. Biol. Chem. 278 (2): 1268–72. doi:10.1074/jbc.M209514200. PMID 12411432.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Heilig R, Eckenberg R, Petit JL, et al. (2003). "The DNA sequence and analysis of human chromosome 14". Nature. 421 (6923): 601–7. Bibcode:2003Natur.421..601H. doi:10.1038/nature01348. PMID 12508121.
Johnson KR, Johnson KY, Becker KP, et al. (2003). "Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability". J. Biol. Chem. 278 (36): 34541–7. doi:10.1074/jbc.M301741200. PMID 12815058.
Le Stunff H, Mikami A, Giussani P, et al. (2004). "Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis". J. Biol. Chem. 279 (33): 34290–7. doi:10.1074/jbc.M404907200. PMID 15180992.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Giussani P, Maceyka M, Le Stunff H, et al. (2006). "Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide". Mol. Cell. Biol. 26 (13): 5055–69. doi:10.1128/MCB.02107-05. PMC 1489178. PMID 16782891.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

This article on a gene on human chromosome 14 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000285281 GRCh38: Ensembl release 89: ENSG00000126821, ENSG00000285281 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021054 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10859351-5] Mandala SM, Thornton R, Galve-Roperh I, Poulton S, Peterson C, Olivera A, Bergstrom J, Kurtz MB, Spiegel S (Aug 2000). "Molecular cloning and characterization of a lipid phosphohydrolase that degrades sphingosine-1- phosphate and induces cell death". Proc Natl Acad Sci U S A. 97 (14): 7859–64. Bibcode:2000PNAS...97.7859M. doi:10.1073/pnas.120146897. PMC 16635. PMID 10859351.

[entrez-6] "Entrez Gene: SGPP1 sphingosine-1-phosphate phosphatase 1".

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References

Further reading