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Rana P Singh

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Prof Rana P Singh
Prof Rana Pratap Singh
Born01 December 1969
NationalityIndian
Alma materJawaharlal Nehru University, Colorado University
SpouseAruna Singh
ChildrenAyushi
Scientific career
InstitutionsJawaharlal Nehru University, Colorado University, Central University of Gujarat
Doctoral advisorProf A. Ramesha Rao
Websiterpscancerlab.com

Prof Rana P Singh is an Indian cancer scientist[1] and professor at the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi.

Prof Singh is a university administrator[2] and acknowledged for creating new departments, schools and research centres in India.[3][4]

His own research encompasses a broad range of topics, including cancer stem cells, spheroids/organoids, DNA repair mechanisms, and the effects of microgravity on radiobiology.[5] Singh is also noted for his work in cell signaling, exploring the complex interactions that govern cellular behavior and cancer progression. His contributions to these areas have significantly advanced the understanding of cancer and its treatment.[6] He is highly cited scientist and has published over 100 research papers in world's leading scientific journals like Nature,[7][8] Oxford Academic,[9] Harvard Catalyst,[10] American Association for Cancer Research Journal[11] , etc

Early life and education

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Prof. Rana P. Singh completed his Ph.D. in life sciences with a specialisation in cancer biology from Jawaharlal Nehru University, New Delhi, India, in 2000. Prior to this, he earned his M.Sc. in life sciences from Jawaharlal Nehru University. He obtained his B.Sc. in zoology, botany, and chemistry from Ewing Christian College, University of Allahabad, Uttar Pradesh, India.[12]

He went to work with University of Colorado, where he worked as research scholar and later joined as an assistant professor.

Administrative positions

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Rana P Singh started Special Centre for Systems Medicine[13] at Jawaharlal Nehru University (JNU) and is currently chairperson of the [14] centre since 2021. This center integrates various scientific disciplines to enhance healthcare merges systems biology, computational biology, high-throughput data analysis, metabolomics, transcriptomics, regulomics, phenomics, and pharmacogenomics etc. This field also incorporates biobanking, data analytics, and animal studies to develop advanced diagnostic and prognostic technologies aimed at improving healthcare outcomes. Singh’s efforts in founding this center align with his vision of promoting interdisciplinary approaches within medical science at JNU as per National Education Policy 2020.[15]

He also established the School of Life Sciences as its founding dean at Central University of Gujarat in 2010–12 and established the research facilities for students and faculties of the university.

In addition to his current role, Singh served as rector[16] (pro-vice chancellor) of JNU from May 2017 to 2022[17] and has been the president of the Institutional Innovation Council[18] at JNU since 2019.[19] His contributions to the university also include serving as dean of students,[20] court member, and executive council member. Prior to his tenure at JNU, he held key positions at the Central University of Gujarat, including dean of students’ welfare,[21] dean of the School of Life Sciences, and dean of the School of Environmental Sciences, as well as provost and chairman of the admission committee.

Academic career

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Prof. Rana P. Singh has had a distinguished career in cancer biology, with a notable academic trajectory spanning multiple prestigious institutions. Since 2012, he has been serving as a professor of cancer biology at the School of Life Sciences, Jawaharlal Nehru University (JNU), New Delhi, India. Concurrently, from 2012 to 2016, he held the position of professor-adjunct at the School of Life Sciences, Central University of Gujarat, Gandhinagar, where he previously served as a professor from 2010 to 2012. His earlier academic appointments include his role as an Associate Professor of Molecular Cancer Biology at JNU from 2006 to 2010, and an assistant professor-research at the Department of Pharmaceutical Sciences, School of Pharmacy, University of Colorado Denver, from 2003 to 2006. He also worked as a research associate at the same department from 2001 to 2003, following a Post-doctoral Research Fellowship at the Center for Cancer Causation and Prevention, AMC Cancer Research Center, Lakewood, Colorado, from 2000 to 2001. In 2014, he further expanded his international academic experience as a Visiting Scientist at the University of California, Riverside, USA.

Awards and honours

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  • Indo-US Science and Technology Forum (IUSSTF) Award (2019): Dr. Rana P. Singh was awarded for establishing the "Centre for Integrative Cancer Biology and Therapeutics," a Virtual Networked Centre in collaboration with Jawaharlal Nehru University (JNU) and Stanford University/Oregon Health & Science University (OHSU), Portland, USA.[22]
  • ICMR International Fellowship for Young Biomedical Scientists (2013–14): Awarded by the Indian Council of Medical Research (ICMR) for research conducted at the University of California, Riverside, USA in 2014.[23][24]
  • Post-doctoral Trainee Award for Prostate Cancer Research (2003): Conferred by the U.S. Army Medical Research and Materiel Command, Department of Defense, USA, in recognition of his contributions to prostate cancer research.[25]
  • Scholar-in-Training Award (2002): Presented by the American Association for Cancer Research, Philadelphia, PA, USA, recognising his early career achievements in cancer research.[26]

Research Publications

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Professor Rana P Singh of Jawaharlal Nehru University (JNU) is a highly accomplished researcher with an extensive body of work in the field of biological sciences. His research has garnered significant recognition, with over 15,876 citations and an h-index of 78 and i10-index of 151, reflecting the impact and quality of his contributions.[27]

As per Google Scholars, since 2019, he has achieved more than 5,084 citations, further solidifying his influence in the scientific community. His work includes more than 200 research articles published in high-impact journals, including prestigious journals like Nature, Springer, Elsevier , Wiley and those of the American Association for Cancer Research (AACR). Prof. Singh's research spans various areas, contributing to the advancement of cancer biology, stem cell research, and other critical fields in life sciences.

His lab has produced some very good data while doing research on effects of microgravity on human cells.

Books, Chapters and Articles

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Prof Singh has written many book chapters on cancer biology and a complete book "Breast Cancer: Biology, Prevention and Treatment"[28] . Some of his notable writings are

  • Mechanisms of Resistance in Head and Neck Cancers. N.p.: Frontiers Media SA, 2022.[29]
  • Cancer Research. United States: Waverly Press, 2009.[30]
  • Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells[31]
  • Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells.[32]
Caption text
Platform Id
Vidwan[33] 56738
Scopus[34] 7407266148
Orcid[35] 0000-0003-4261-7044
Google Scholars[36] ef7Y-6YAAAAJ

References

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  1. ^ Tailor, Dhanir; Going, Catherine C.; Resendez, Angel; Kumar, Vineet; Nambiar, Dhanya K.; Li, Yang; Dheeraj, Arpit; LaGory, Edward Lewis; Ghoochani, Ali; Birk, Alisha M.; Stoyanova, Tanya; Ye, Jiangbin; Giaccia, Amato J.; Le, Quynh-Thu; Singh, Rana P.; Sledge, George W.; Pitteri, Sharon J.; Malhotra, Sanjay V. (February 2021). "Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer". British Journal of Cancer. 124 (3): 604–615. doi:10.1038/s41416-020-01137-4. ISSN 1532-1827. PMC 7851402. PMID 33139797.
  2. ^ "Sri Sri to give lecture at JNU on Nov 13". The Hindu. 5 November 2017.
  3. ^ "JNU To Start 4-year UG Programmes, Online Courses In Non-Technical Subjects". Outlook India. 20 November 2020.
  4. ^ "JNU to establish special centre for systems medicine". The Hindu. 19 November 2020. Retrieved 20 November 2020.
  5. ^ "Rana P Singh". Google Scholar.
  6. ^ "Press Trust Of India". www.ptinews.com.
  7. ^ Chandraker, Sandip Kumar; Lal, Mishri; Khanam, Farheen; Dhruve, Preeti; Singh, Rana P.; Shukla, Ravindra (25 May 2022). "Therapeutic potential of biogenic and optimized silver nanoparticles using Rubia cordifolia L. leaf extract". Scientific Reports. 12 (1): 8831. Bibcode:2022NatSR..12.8831C. doi:10.1038/s41598-022-12878-y. ISSN 2045-2322. PMC 9133087. PMID 35614187.
  8. ^ Tailor, Dhanir; Going, Catherine C.; Resendez, Angel; Kumar, Vineet; Nambiar, Dhanya K.; Li, Yang; Dheeraj, Arpit; LaGory, Edward Lewis; Ghoochani, Ali; Birk, Alisha M.; Stoyanova, Tanya; Ye, Jiangbin; Giaccia, Amato J.; Le, Quynh-Thu; Singh, Rana P.; Sledge, George W.; Pitteri, Sharon J.; Malhotra, Sanjay V. (February 2021). "Novel Aza-podophyllotoxin derivative induces oxidative phosphorylation and cell death via AMPK activation in triple-negative breast cancer". British Journal of Cancer. 124 (3): 604–615. doi:10.1038/s41416-020-01137-4. ISSN 1532-1827. PMC 7851402. PMID 33139797.
  9. ^ Singh, R. P. (1 March 2003). "Inositol hexaphosphate inhibits growth, and induces G1 arrest and apoptotic death of prostate carcinoma DU145 cells: modulation of CDKI-CDK-cyclin and pRb-related protein-E2F complexes". Carcinogenesis. 24 (3): 555–563. doi:10.1093/carcin/24.3.555. PMID 12663518.
  10. ^ "Akash Sabarwal | Harvard Catalyst Profiles | Harvard Catalyst". Connects.catalyst.harvard.edu.
  11. ^ Gu, Mallikarjuna; Singh, Rana P.; Dhanalakshmi, Sivanandhan; Mohan, Sarumathi; Agarwal, Rajesh (2006). "Differential effect of silibinin on E2F". Molecular Cancer Therapeutics. 5 (8): 2121–2130. doi:10.1158/1535-7163.MCT-06-0052. PMID 16928834.
  12. ^ "Jawaharlal Nehru University". www.jnu.ac.in.
  13. ^ "JNU To Start 4-year UG Programmes, Online Courses In Non-Technical Subjects". Outlook India. 20 November 2020.
  14. ^ "JNU to establish special centre for systems medicine". The Hindu. 19 November 2020. Retrieved 20 November 2020.
  15. ^ "Jawaharlal Nehru University considers introducing four-year undergraduate programmes". The New Indian Express. 20 November 2020.
  16. ^ "JNU to launch SCEL platform: Digital courses to be offered in various disciplines". India Today. 29 November 2017. Retrieved 29 November 2017.
  17. ^ "New JNU V-C starts putting team in place". The Indian Express. 16 March 2022.
  18. ^ "Innovation Sprint launched at JNU". The Times of India. 18 April 2021.
  19. ^ "ATAL INCUBATION CENTRE-JNU FOUNDATION FOR INNOVATION" (PDF). Jawaharlal Nehru University. Retrieved 17 July 2021.
  20. ^ "JNU students block admin building protesting new admission rules". The Times of India. 10 February 2017.
  21. ^ Annual Report 2021 (PDF). Central University of Gujarat. p. 4.
  22. ^ "Indo-U.S. Virtual Networked Centers - Iusstf". iusstf.org.
  23. ^ "Indian Council for Medical Research" (PDF). icmr.nic.in.
  24. ^ "Rana P. Singh | Welcome to Jawaharlal Nehru University". www.jnu.ac.in.
  25. ^ "India Cancer Research Database". www.incredb.org.
  26. ^ "Jawaharlal Nehru University". www.jnu.ac.in.
  27. ^ "Scholar Profile". Google Scholars.
  28. ^ P Singh, Rana. Red Flower Publications. ISBN 978-81-930735-0-6. Retrieved 1 January 2015.
  29. ^ Mechanisms of Resistance in Head and Neck Cancers. Frontiers Media SA. 8 August 2022. ISBN 978-2-88976-732-8.
  30. ^ Cancer Research. Waverly Press. February 2009.
  31. ^ Singh, Ragini; Jaiswal, Aishwarya; Singh, Rana P. (March 2024). "Simulated microgravity induces DNA damage concurrent with impairment of DNA repair and activation of cell-type specific DNA damage response in microglial and glioblastoma cells". Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1871 (3): 119679. doi:10.1016/j.bbamcr.2024.119679. PMID 38272357.
  32. ^ Singh, Ragini; Rajput, Mohit; Singh, Rana P. (November 2021). "Simulated microgravity triggers DNA damage and mitochondria-mediated apoptosis through ROS generation in human promyelocytic leukemic cells". Mitochondrion. 61: 114–124. doi:10.1016/j.mito.2021.09.006. PMID 34571251.
  33. ^ "Vidwan Profile Page". vidwan.inflibnet.ac.in.
  34. ^ "Singh Rana P". Scopus.
  35. ^ "ORCID". orcid.org.
  36. ^ "Rana P Singh". scholar.google.co.in.
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