RNF34

RNF34
Identifiers
Aliases	RNF34, CARP-1, CARP1, RFI, RIF, RIFF, hRFI, ring finger protein 34
External IDs	OMIM: 608299; MGI: 2153340; HomoloGene: 11839; GeneCards: RNF34; OMA:RNF34 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) Band 12q24.31 Start 121,400,083 bp End 121,430,623 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 F Start 122,988,111 bp End 123,009,354 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Skeletal muscle tissue of rectus abdominis Skeletal muscle tissue of biceps brachii triceps brachii muscle glutes ganglionic eminence muscle of thigh gonad middle temporal gyrus Brodmann area 23 Top expressed in zygote secondary oocyte primary oocyte tail of embryo right ventricle medial ganglionic eminence genital tubercle spermatid granulocyte temporal muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding phosphatidylinositol phosphate binding p53 binding ubiquitin protein ligase binding protein binding ubiquitin protein ligase activity ubiquitin-protein transferase activity transferase activity Cellular component cytoplasm endomembrane system nucleus membrane plasma membrane nuclear speck nucleoplasm cytosol nuclear body Biological process negative regulation of signal transduction by p53 class mediator negative regulation of extrinsic apoptotic signaling pathway via death domain receptors nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway protein K48-linked ubiquitination negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis apoptotic process regulation of oxygen metabolic process cellular response to cold protein ubiquitination proteasome-mediated ubiquitin-dependent protein catabolic process ubiquitin-dependent protein catabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 80196 80751 Ensembl ENSG00000170633 ENSMUSG00000029474 UniProt Q969K3 Q99KR6 RefSeq (mRNA) NM_194271 NM_001256858 NM_025126 NM_001394208 NM_030564 RefSeq (protein) NP_001243787 NP_079402 NP_919247 NP_085041 Location (UCSC) Chr 12: 121.4 – 121.43 Mb Chr 5: 122.99 – 123.01 Mb PubMed search
Wikidata
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E3 ubiquitin-protein ligase RNF34 is an enzyme that in humans is encoded by the RNF34 gene.

The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• McDonald ER, El-Deiry WS (2004). "Suppression of caspase-8- and -10-associated RING proteins results in sensitization to death ligands and inhibition of tumor cell growth". Proc. Natl. Acad. Sci. U.S.A. 101 (16): 6170–5. Bibcode:2004PNAS..101.6170M. doi:10.1073/pnas.0307459101. PMC 395941. PMID 15069192.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Sasaki S, Watanabe T, Konishi T, et al. (2005). "Effects of expression of hRFI on adenoma formation and tumor progression in colorectal adenoma-carcinoma sequence". J. Exp. Clin. Cancer Res. 23 (3): 507–12. PMID 15595643.
• Konishi T, Sasaki S, Watanabe T, et al. (2005). "Overexpression of hRFI (human ring finger homologous to inhibitor of apoptosis protein type) inhibits death receptor-mediated apoptosis in colorectal cancer cells". Mol. Cancer Ther. 4 (5): 743–50. doi:10.1158/1535-7163.MCT-05-0020. PMID 15897238.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.