Repulsive guidance molecule B

RGMB
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4BQ6, 4BQ7, 4BQ8, 4UHZ, 4UI0, 4UI2
Identifiers
Aliases	RGMB, DRAGON, repulsive guidance molecule family member b, repulsive guidance molecule BMP co-receptor b
External IDs	OMIM: 612687; MGI: 1916049; HomoloGene: 65355; GeneCards: RGMB; OMA:RGMB - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	98,798,643 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	15,831,039 bp
RNA expression pattern
	Top expressed in
	mucosa of ileum; ; pylorus; ; skin of arm; ; skin of thigh; ; tibialis anterior muscle; ; cardia; ; cardiac muscle tissue of right atrium; ; rectum; ; deltoid muscle; ; spinal ganglia;
	Top expressed in
	Rostral migratory stream; ; otolith organ; ; utricle; ; Paneth cell; ; lateral habenular nucleus; ; paraventricular nucleus of thalamus; ; medial habenular nucleus; ; spinal ganglia; ; lumbar spinal ganglion; ; sciatic nerve;
	More reference expression data
	n/a
Gene ontology
Molecular function	coreceptor activity; identical protein binding; protein binding;
Cellular component	membrane raft; anchored component of membrane; plasma membrane; membrane; endoplasmic reticulum-Golgi intermediate compartment; anchored component of plasma membrane;
Biological process	positive regulation of transcription, DNA-templated; signal transduction; BMP signaling pathway; cell adhesion;
	Sources:Amigo / QuickGO
Orthologs
	285704
	68799
	ENSG00000174136
	ENSMUSG00000048027
	Q6NW40
	Q7TQ33
NM_001012761; NM_173670; NM_001366508; NM_001366509; NM_001366510;
	NM_001366511
	NM_178615
	NP_001012779; NP_001353437; NP_001353438; NP_001353439; NP_001353440
	NP_848730
	Wikidata
View/Edit Human	View/Edit Mouse

Repulsive guidance molecule B (RGMb), also known as DRAGON (DRG11-responsive axonal guidance and outgrowth of neurite), is a bone morphogenetic protein (BMP) co-receptor of the repulsive guidance molecule family.^[5] In humans this protein is encoded by the RGMB gene.^[6]

Function

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see also RGMA and RGMC) and contributes to the patterning of the developing nervous system.^[7]^[8]

There is a potential association between RGMs and cancer bone metastasis, as RGMs coordinate bone morphogenetic protein (BMP) signaling. RGMB may act as a negative regulator in vitro in breast cancer and prostate cancer through BMP signalling.^[9]^[10] Furthermore, aberrant expression of RGMs was indicated in breast cancer. The perturbed expression was associated with disease progression and poor prognosis.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000174136 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000048027 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Corradini, Elena; Babitt, Jodie L.; Lin, Herbert Y. (October 2009). "The RGM/DRAGON family of BMP co-receptors". Cytokine & Growth Factor Reviews. 20 (5–6): 389–398. doi:10.1016/j.cytogfr.2009.10.008. PMC 3715994. PMID 19897400.
^ "Entrez Gene: RGM domain family".
^ Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ (April 2005). "DRAGON, a bone morphogenetic protein co-receptor". J. Biol. Chem. 280 (14): 14122–9. doi:10.1074/jbc.M410034200. PMID 15671031.
^ Severyn CJ, Shinde U, Rotwein P (September 2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". Biochem. J. 422 (3): 393–403. doi:10.1042/BJ20090978. PMC 4242795. PMID 19698085.
^ Li J, Ye L, Sanders AJ, Jiang WG (March 2012). "Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling". J Cell Biochem. 113 (7): 2523–31. doi:10.1002/jcb.24128. PMID 22415859. S2CID 35629616.
^ Li J, Ye L, Kynaston HG, Jiang WG (February 2012). "Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells". Int. J. Oncol. 40 (2): 544–50. doi:10.3892/ijo.2011.1251. PMID 22076499.
^ Li J, Ye L, Mansel RE, Jiang WG (May 2011). "Potential prognostic value of repulsive guidance molecules in breast cancer". Anticancer Res. 31 (5): 1703–11. PMID 21617229.

Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Samad TA, Srinivasan A, Karchewski LA, et al. (2004). "DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties". J. Neurosci. 24 (8): 2027–36. doi:10.1523/JNEUROSCI.4115-03.2004. PMC 6730385. PMID 14985445.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000174136 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048027 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Corradini, Elena; Babitt, Jodie L.; Lin, Herbert Y. (October 2009). "The RGM/DRAGON family of BMP co-receptors". Cytokine & Growth Factor Reviews. 20 (5–6): 389–398. doi:10.1016/j.cytogfr.2009.10.008. PMC 3715994. PMID 19897400.

[entrez-6] "Entrez Gene: RGM domain family".

[pmid15671031-7] Samad TA, Rebbapragada A, Bell E, Zhang Y, Sidis Y, Jeong SJ, Campagna JA, Perusini S, Fabrizio DA, Schneyer AL, Lin HY, Brivanlou AH, Attisano L, Woolf CJ (April 2005). "DRAGON, a bone morphogenetic protein co-receptor". J. Biol. Chem. 280 (14): 14122–9. doi:10.1074/jbc.M410034200. PMID 15671031.

[pmid19698085-8] Severyn CJ, Shinde U, Rotwein P (September 2009). "Molecular biology, genetics and biochemistry of the repulsive guidance molecule family". Biochem. J. 422 (3): 393–403. doi:10.1042/BJ20090978. PMC 4242795. PMID 19698085.

[pmid22415859-9] Li J, Ye L, Sanders AJ, Jiang WG (March 2012). "Repulsive guidance molecule B (RGMB) plays negative roles in breast cancer by coordinating BMP signaling". J Cell Biochem. 113 (7): 2523–31. doi:10.1002/jcb.24128. PMID 22415859. S2CID 35629616.

[pmid22076499-10] Li J, Ye L, Kynaston HG, Jiang WG (February 2012). "Repulsive guidance molecules, novel bone morphogenetic protein co-receptors, are key regulators of the growth and aggressiveness of prostate cancer cells". Int. J. Oncol. 40 (2): 544–50. doi:10.3892/ijo.2011.1251. PMID 22076499.

[pmid21617229-11] Li J, Ye L, Mansel RE, Jiang WG (May 2011). "Potential prognostic value of repulsive guidance molecules in breast cancer". Anticancer Res. 31 (5): 1703–11. PMID 21617229.

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Function

References

Further reading