Ras-interacting protein 1

RASIP1
Identifiers
Aliases	RASIP1, RAIN, Ras interacting protein 1
External IDs	OMIM: 609623; MGI: 1917153; HomoloGene: 9847; GeneCards: RASIP1; OMA:RASIP1 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	48,740,610 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	45,288,517 bp
RNA expression pattern
	Top expressed in
	right lung; ; upper lobe of left lung; ; apex of heart; ; spleen; ; subcutaneous adipose tissue; ; lower lobe of lung; ; left uterine tube; ; left ventricle; ; right auricle; ; body of uterus;
	Top expressed in
	vascular endothelium; ; interventricular septum; ; right lung; ; left lung; ; left lung lobe; ; capillary; ; lactiferous gland; ; vasculature of trunk; ; cardiac muscle tissue of left ventricle; ; right lung lobe;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; protein homodimerization activity; GTPase binding;
Cellular component	perinuclear region of cytoplasm; cytoplasm; Golgi stack; Golgi apparatus; cell-cell junction; protein-containing complex;
Biological process	vasculogenesis; regulation of GTPase activity; negative regulation of autophagy; branching morphogenesis of an epithelial tube; angiogenesis; signal transduction; positive regulation of integrin activation; negative regulation of Rho protein signal transduction; negative regulation of membrane permeability; negative regulation of Rho-dependent protein serine/threonine kinase activity;
	Sources:Amigo / QuickGO
Orthologs
	54922
	69903
	ENSG00000105538
	ENSMUSG00000044562
	Q5U651
	Q3U0S6
	NM_017805
	NM_028544; NM_027253
	NP_060275
	NP_082820
	Wikidata
View/Edit Human	View/Edit Mouse

Ras-interacting protein 1 (Rain), is a protein that in humans is encoded by the RASIP1 gene.^[5]

Function

It is required for the proper formation of vascular structures that develop via both vasculogenesis and angiogenesis.^[6]
Acts as a critical and vascular-specific regulator of GTPase signaling, cell architecture, and adhesion, which is essential for endothelial cell morphogenesis and blood vessel tubulogenesis.^[7]^[8]^[9]
Regulates the activity of Rho GTPases in part by recruiting ARHGAP29 and suppressing RhoA signaling and dampening ROCK and MYH9 activities in endothelial cells.^[10]^[11]

Clinical significance

A recent genome-wide association study (GWAS) has found that genetic variations in RASIP1 are associated with late-onset sporadic Alzheimer’s disease (LOAD). However, it's unknown how RASIP1 mutation contributes to disease.^[12]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105538 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044562 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein". www.uniprot.org. Retrieved 2021-12-11. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.
^ Wilson CW, Ye W (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration. 8 (2): 76–83. doi:10.4161/cam.28115. PMC 4049864. PMID 24622510.
^ Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, et al. (April 2016). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis. 19 (2): 173–190. doi:10.1007/s10456-016-9498-5. PMC 4808411. PMID 26897025.
^ Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, et al. (August 2018). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development. 145 (17): dev165092. doi:10.1242/dev.165092. PMC 6141773. PMID 30042182.
^ Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (May 2009). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology. 329 (2): 269–279. doi:10.1016/j.ydbio.2009.02.033. PMC 2683470. PMID 19272373.
^ Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, et al. (September 2016). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research. 119 (7): 810–826. doi:10.1161/CIRCRESAHA.116.309094. PMC 5026621. PMID 27486147.
^ Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–22361. doi:10.1074/jbc.M312867200. PMID 15031288.
^ Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMC 10243600. PMID 34493870. S2CID 237442349.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000105538 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044562 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] "RASIP1 - Ras-interacting protein 1 - Homo sapiens (Human) - RASIP1 gene & protein". www.uniprot.org. Retrieved 2021-12-11. Text was copied from this source, which is available under a Creative Commons Attribution 4.0 International License.

[6] Wilson CW, Ye W (2014). "Regulation of vascular endothelial junction stability and remodeling through Rap1-Rasip1 signaling". Cell Adhesion & Migration. 8 (2): 76–83. doi:10.4161/cam.28115. PMC 4049864. PMID 24622510.

[7] Koo Y, Barry DM, Xu K, Tanigaki K, Davis GE, Mineo C, et al. (April 2016). "Rasip1 is essential to blood vessel stability and angiogenic blood vessel growth". Angiogenesis. 19 (2): 173–190. doi:10.1007/s10456-016-9498-5. PMC 4808411. PMID 26897025.

[8] Liu X, Gu X, Ma W, Oxendine M, Gil HJ, Davis GE, et al. (August 2018). "Rasip1 controls lymphatic vessel lumen maintenance by regulating endothelial cell junctions". Development. 145 (17): dev165092. doi:10.1242/dev.165092. PMC 6141773. PMID 30042182.

[9] Xu K, Chong DC, Rankin SA, Zorn AM, Cleaver O (May 2009). "Rasip1 is required for endothelial cell motility, angiogenesis and vessel formation". Developmental Biology. 329 (2): 269–279. doi:10.1016/j.ydbio.2009.02.033. PMC 2683470. PMID 19272373.

[10] Barry DM, Koo Y, Norden PR, Wylie LA, Xu K, Wichaidit C, et al. (September 2016). "Rasip1-Mediated Rho GTPase Signaling Regulates Blood Vessel Tubulogenesis via Nonmuscle Myosin II". Circulation Research. 119 (7): 810–826. doi:10.1161/CIRCRESAHA.116.309094. PMC 5026621. PMID 27486147.

[11] Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–22361. doi:10.1074/jbc.M312867200. PMID 15031288.

[12] Wightman DP, Jansen IE, Savage JE, Shadrin AA, Bahrami S, Holland D, et al. (September 2021). "A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimer's disease". Nature Genetics. 53 (9): 1276–1282. doi:10.1038/s41588-021-00921-z. hdl:1871.1/61f01aa9-6dc7-4213-be2a-d3fe622db488. PMC 10243600. PMID 34493870. S2CID 237442349.

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