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PRPF3

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PRPF3
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRPF3, pre-mRNA processing factor 3, HPRP3, HPRP3P, PRP3, Prp3p, RP18, SNRNP90
External IDsOMIM: 607301; MGI: 1918017; HomoloGene: 3447; GeneCards: PRPF3; OMA:PRPF3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004698
NM_001350529

NM_027541
NM_001316751

RefSeq (protein)

NP_004689
NP_001337458

NP_001303680
NP_081817

Location (UCSC)Chr 1: 150.32 – 150.35 MbChr 3: 95.74 – 95.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

U4/U6 small nuclear ribonucleoprotein Prp3 is a protein that in humans is encoded by the PRPF3 gene.[5]

Function

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The removal of introns from nuclear pre-mRNAs occurs on complexes called spliceosomes, which are made up of 4 small nuclear ribonucleoprotein (snRNP) particles and an undefined number of transiently associated splicing factors. PRPF3 is one of several proteins that associate with U4 and U6 snRNPs.[supplied by OMIM][5]

Interactions

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PRPF3 has been shown to interact with DVL3.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000117360Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015748Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: PRPF3 PRP3 pre-mRNA processing factor 3 homolog (S. cerevisiae)".
  6. ^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.

Further reading

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