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PPP5C

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(Redirected from PPP5C (gene))
PPP5C
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP5C, PP5, PPP5, PPT, protein phosphatase 5 catalytic subunit
External IDsOMIM: 600658; MGI: 102666; HomoloGene: 4550; GeneCards: PPP5C; OMA:PPP5C - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_006247
NM_001204284

NM_011155

RefSeq (protein)

NP_001191213
NP_006238

NP_035285

Location (UCSC)Chr 19: 46.35 – 46.39 MbChr 7: 16.74 – 16.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 5 is an enzyme that in humans is encoded by the PPP5C gene.[5][6]

Interactions

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PPP5C has been shown to interact with ASK1,[7] CRY2[8] GNA12.[9] and Rac1,[10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000011485Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003099Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Yong WH, Ueki K, Chou D, Reeves SA, von Deimling A, Gusella JF, Mohrenweiser HW, Buckler AJ, Louis DN (Sep 1995). "Cloning of a highly conserved human protein serine-threonine phosphatase gene from the glioma candidate region on chromosome 19q13.3". Genomics. 29 (2): 533–6. doi:10.1006/geno.1995.9972. PMID 8666404.
  6. ^ "Entrez Gene: PPP5C Protein phosphatase 5, catalytic subunit".
  7. ^ Morita K, Saitoh M, Tobiume K, Matsuura H, Enomoto S, Nishitoh H, Ichijo H (Nov 2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". The EMBO Journal. 20 (21): 6028–36. doi:10.1093/emboj/20.21.6028. PMC 125685. PMID 11689443.
  8. ^ Zhao S, Sancar A (Nov 1997). "Human blue-light photoreceptor hCRY2 specifically interacts with protein serine/threonine phosphatase 5 and modulates its activity". Photochemistry and Photobiology. 66 (5): 727–31. doi:10.1111/j.1751-1097.1997.tb03214.x. PMID 9383998. S2CID 32804361.
  9. ^ Yamaguchi Y, Katoh H, Mori K, Negishi M (Aug 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367. S2CID 11485795.
  10. ^ Chatterjee A, Wang L, Armstrong DL, Rossie S (Feb 2010). "Activated Rac1 GTPase translocates protein phosphatase 5 to the cell membrane and stimulates phosphatase activity in vitro". The Journal of Biological Chemistry. 285 (6): 3872–82. doi:10.1074/jbc.M109.088427. PMC 2823530. PMID 19948726.

Further reading

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