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PPP1CC

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PPP1CC
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPPP1CC, PP-1G, PP1C, PPP1G, protein phosphatase 1 catalytic subunit gamma
External IDsOMIM: 176914; MGI: 3647492; HomoloGene: 100608; GeneCards: PPP1CC; OMA:PPP1CC - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001244974
NM_002710

XM_006508415

RefSeq (protein)

NP_001231903
NP_002701

NP_038664

Location (UCSC)Chr 12: 110.72 – 110.74 MbChr 5: 122.16 – 122.18 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit is an enzyme that in humans is encoded by the PPP1CC gene.[5]

Interactions

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PPP1CC has been shown to interact with PPP1R15A,[6][7] SMARCB1,[6] TLX1[8] and PPP1R9B.[9][10]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000186298Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004455Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: PPP1CC Protein phosphatase 1, catalytic subunit, gamma isoform".
  6. ^ a b Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (Aug 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31). United States: 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
  7. ^ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (Oct 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20). United States: 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
  8. ^ Kawabe T, Muslin A J, Korsmeyer S J (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615). ENGLAND: 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. ISSN 0028-0836. PMID 9009195. S2CID 608633.
  9. ^ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (Apr 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14). UNITED STATES: 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
  10. ^ Smith FD, Oxford G S, Milgram S L (Jul 1999). "Association of the D2 dopamine receptor third cytoplasmic loop with spinophilin, a protein phosphatase-1-interacting protein". J. Biol. Chem. 274 (28). UNITED STATES: 19894–900. doi:10.1074/jbc.274.28.19894. ISSN 0021-9258. PMID 10391935.

Further reading

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