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PON3

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PON3
Identifiers
AliasesPON3, paraoxonase 3
External IDsOMIM: 602720; MGI: 106686; HomoloGene: 37371; GeneCards: PON3; OMA:PON3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000940

NM_173006
NM_001363812

RefSeq (protein)

NP_000931

NP_766594
NP_001350741

Location (UCSC)Chr 7: 95.36 – 95.4 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Paraoxonase 3, also known as PON3, is a protein which in humans is encoded by the PON3 gene.[4][5]

Function

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This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105852Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Primo-Parmo SL, Sorenson RC, Teiber J, La Du BN (May 1996). "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family". Genomics. 33 (3): 498–507. doi:10.1006/geno.1996.0225. PMID 8661009.
  5. ^ a b "Entrez Gene: PON3 paraoxonase 3".

Further reading

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