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POM121

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POM121
Identifiers
AliasesPOM121, P145, POM121A, POM121 transmembrane nucleoporin
External IDsOMIM: 615753; MGI: 2137624; HomoloGene: 70878; GeneCards: POM121; OMA:POM121 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001257190
NM_172020
NM_001367610

NM_148932

RefSeq (protein)

NP_001244119
NP_742017
NP_001354539

NP_683734

Location (UCSC)Chr 7: 72.88 – 72.95 MbChr 5: 135.4 – 135.42 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Nuclear envelope pore membrane protein POM 121 is a protein that in humans is encoded by the POM121 gene.[5][6][7] Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined.[8]

Function

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The nuclear envelope creates distinct nuclear and cytoplasmic compartments in eukaryotic cells. It consists of two concentric membranes perforated by nuclear pores, large protein complexes that form aqueous channels to regulate the flow of macromolecules between the nucleus and the cytoplasm. These complexes are composed of at least 100 different polypeptide subunits, many of which belong to the nucleoporin family. This gene encodes a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is an integral membrane protein that localizes to the central spoke ring complex and participates in anchoring the nuclear pore complex to the nuclear envelope.[8]

Antibodies against this protein can be used to identify the nuclear envelope in immunofluorescence experiments.[9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196313Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053293Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Hallberg E, Wozniak RW, Blobel G (Aug 1993). "An integral membrane protein of the pore membrane domain of the nuclear envelope contains a nucleoporin-like region". J Cell Biol. 122 (3): 513–21. doi:10.1083/jcb.122.3.513. PMC 2119659. PMID 8335683.
  6. ^ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Dec 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  7. ^ Funakoshi T, Maeshima K, Yahata K, Sugano S, Imamoto F, Imamoto N (Oct 2007). "Two distinct human POM121 genes: requirement for the formation of nuclear pore complexes". FEBS Lett. 581 (25): 4910–6. doi:10.1016/j.febslet.2007.09.021. PMID 17900573. S2CID 12819086.
  8. ^ a b "Entrez Gene: POM121 POM121 membrane glycoprotein (homo sapiens)".
  9. ^ Kihlmark M, Imreh G, Hallberg E (October 2001). "Sequential degradation of proteins from the nuclear envelope during apoptosis". J. Cell Sci. 114 (Pt 20): 3643–53. doi:10.1242/jcs.114.20.3643. PMID 11707516.

Further reading

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