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POLR2J2

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(Redirected from POLR2J2 (gene))
POLR2J2
Identifiers
AliasesPOLR2J2, polymerase (RNA) II (DNA directed) polypeptide J2, HRPB11B, RPB11b1, polymerase (RNA) II subunit J2, RNA polymerase II subunit J2, RPB11b2, POLR2J3
External IDsOMIM: 609881; HomoloGene: 129653; GeneCards: POLR2J2; OMA:POLR2J2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145325
NM_032958
NM_032959

n/a

RefSeq (protein)

NP_001091084
NP_116581

n/a

Location (UCSC)Chr 7: 102.67 – 102.67 Mbn/a
PubMed search[2]n/a
Wikidata
View/Edit Human

DNA directed RNA polymerase II polypeptide J-related gene, also known as POLR2J2, is a human gene.[3]

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J.

Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo.[3]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000228049Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ a b "Entrez Gene: POLR2J2 DNA directed RNA polymerase II polypeptide J-related gene".

Further reading

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