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PIWIL1

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PIWIL1
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPIWIL1, CT80.1, HIWI, MIWI, PIWI, piwi like RNA-mediated gene silencing 1
External IDsOMIM: 605571; MGI: 1928897; HomoloGene: 37963; GeneCards: PIWIL1; OMA:PIWIL1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001190971
NM_004764

NM_021311

RefSeq (protein)

NP_001177900
NP_004755

NP_067286

Location (UCSC)Chr 12: 130.34 – 130.37 MbChr 5: 128.78 – 128.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.[5][6][7]

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.

The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.[7]

References

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  1. ^ a b c ENSG00000125207 GRCh38: Ensembl release 89: ENSG00000275051, ENSG00000125207Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029423Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (Jan 1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255. PMID 9851978.
  6. ^ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
  7. ^ a b "Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)".

Further reading

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