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PIGB

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PIGB
Identifiers
AliasesPIGB, GPI-MT-III, PIG-B, phosphatidylinositol glycan anchor biosynthesis class B, EIEE80, DEE80
External IDsOMIM: 604122; MGI: 1891825; HomoloGene: 3570; GeneCards: PIGB; OMA:PIGB - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004855

NM_018889

RefSeq (protein)

NP_004846

NP_061377

Location (UCSC)Chr 15: 55.32 – 55.36 MbChr 9: 72.91 – 72.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.[5][6]

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000069943Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000079469Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC 452151. PMID 8861954.
  6. ^ a b "Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

Further reading

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