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PIAS4

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PIAS4
Identifiers
AliasesPIAS4, PIASY, Piasg, ZMIZ6, PIAS-gamma, protein inhibitor of activated STAT 4
External IDsOMIM: 605989; MGI: 2136940; HomoloGene: 104136; GeneCards: PIAS4; OMA:PIAS4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_015897
NM_016149

NM_021501

RefSeq (protein)

NP_056981

NP_067476

Location (UCSC)Chr 19: 4.01 – 4.04 MbChr 10: 80.99 – 81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

E3 SUMO-protein ligase PIAS4 is one of several protein inhibitor of activated STAT (PIAS) proteins. It is also known as protein inhibitor of activated STAT protein gamma (PIASg or PIASy), and is an enzyme that in humans is encoded by the PIAS4 gene.[5][6]

Interactions

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PIAS4 has been shown to interact with Mothers against decapentaplegic homolog 6,[7] Mothers against decapentaplegic homolog 7[7] and Lymphoid enhancer-binding factor 1.[8] PIAS4 has been shown to be responsible for the SUMOylation of inhibited Werner syndrome helicase (WRN) trapped on DNA in microsatellite unstable cancer cells. [9]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000105229Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004934Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu B, Liao J, Rao X, Kushner SA, Chung CD, Chang DD, Shuai K (Sep 1998). "Inhibition of Stat1-mediated gene activation by PIAS1". Proc Natl Acad Sci U S A. 95 (18): 10626–31. Bibcode:1998PNAS...9510626L. doi:10.1073/pnas.95.18.10626. PMC 27945. PMID 9724754.
  6. ^ "Entrez Gene: PIAS4 Protein inhibitor of activated STAT, 4".
  7. ^ a b Imoto, Seiyu; Sugiyama Kenji; Muromoto Ryuta; Sato Noriko; Yamamoto Tetsuya; Matsuda Tadashi (Sep 2003). "Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3". J. Biol. Chem. 278 (36): 34253–8. doi:10.1074/jbc.M304961200. hdl:2115/28123. ISSN 0021-9258. PMID 12815042.
  8. ^ Sachdev, S; Bruhn L; Sieber H; Pichler A; Melchior F; Grosschedl R (Dec 2001). "PIASy, a nuclear matrix-associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies". Genes Dev. 15 (23): 3088–103. doi:10.1101/gad.944801. ISSN 0890-9369. PMC 312834. PMID 11731474.
  9. ^ Rodríguez Pérez F, Natwick D, Schiff L, McSwiggen D, Heckert A, Huey M, Morrison H, Loo M, Miranda RG, Filbin J, Ortega J, Van Buren K, Murnock D, Tao A, Butler R, Cheng K, Tarvestad W, Zhang Z, Gonzalez E, Miller RM, Kelly M, Tang Y, Ho J, Anderson D, Bashore C, Basham S (July 2024). "WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis". Nat. Commun. 15 (6059). doi:10.1038/s41467-024-50178-3. PMC 11258360. PMID 39025847.

Further reading

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