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PFDN5

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PFDN5
Identifiers
AliasesPFDN5, MM-1, MM1, PFD5, prefoldin subunit 5
External IDsOMIM: 604899; MGI: 1928753; HomoloGene: 1972; GeneCards: PFDN5; OMA:PFDN5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_145897
NM_002624
NM_145896

NM_020031
NM_027044

RefSeq (protein)

NP_002615
NP_665904

NP_081320

Location (UCSC)Chr 12: 53.3 – 53.3 MbChr 15: 102.23 – 102.24 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.[5][6][7]

This gene encodes a member of the prefoldin alpha subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. The encoded protein may also repress the transcriptional activity of the proto-oncogene c-Myc. Alternatively spliced transcript variants encoding different isoforms have been described.[7]

Interactions

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PFDN5 has been shown to interact with Myc.[6][8]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123349Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001289Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (May 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/S0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
  6. ^ a b Mori K, Maeda Y, Kitaura H, Taira T, Iguchi-Ariga SM, Ariga H (November 1998). "MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc". The Journal of Biological Chemistry. 273 (45): 29794–800. doi:10.1074/jbc.273.45.29794. PMID 9792694.
  7. ^ a b "Entrez Gene: PFDN5 prefoldin subunit 5".
  8. ^ Fujioka Y, Taira T, Maeda Y, Tanaka S, Nishihara H, Iguchi-Ariga SM, Nagashima K, Ariga H (November 2001). "MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer". The Journal of Biological Chemistry. 276 (48): 45137–44. doi:10.1074/jbc.M106127200. PMID 11567024.

Further reading

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