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PFDN4

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PFDN4
Identifiers
AliasesPFDN4, C1, PFD4, prefoldin subunit 4
External IDsOMIM: 604898; MGI: 1923512; HomoloGene: 37645; GeneCards: PFDN4; OMA:PFDN4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_002623

NM_001013369
NM_001110152
NM_001199902

RefSeq (protein)

NP_002614

n/a

Location (UCSC)Chr 20: 54.21 – 54.23 MbChr 2: 170.34 – 170.36 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Prefoldin subunit 4 is a protein that in humans is encoded by the PFDN4 gene.[5][6][7]

Function

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This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils.[7]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000101132Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052033Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Vainberg IE, Lewis SA, Rommelaere H, Ampe C, Vandekerckhove J, Klein HL, Cowan NJ (May 1998). "Prefoldin, a chaperone that delivers unfolded proteins to cytosolic chaperonin". Cell. 93 (5): 863–73. doi:10.1016/s0092-8674(00)81446-4. PMID 9630229. S2CID 16011829.
  6. ^ Iijima M, Kano Y, Nohno T, Namba M (Apr 1996). "Cloning of cDNA with possible transcription factor activity at the G1-S phase transition in human fibroblast cell lines". Acta Medica Okayama. 50 (2): 73–7. PMID 8744932.
  7. ^ a b Coraboeuf E, Deroubaix E, Hoerter J (May 1976). "Control of ionic permeabilities in normal and ischemic heart". Circulation Research. 38 (5 Suppl 1): I92–8. PMID 5203.

Further reading

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